2-(3-fluorophenyl)-6-methoxy-1-[4-pyridin-4-ylphenyl]-1,2,3,4-tetrahydroisoquinoline

Base Information

Chemical Name:2-(3-fluorophenyl)-6-methoxy-1-[4-pyridin-4-ylphenyl]-1,2,3,4-tetrahydroisoquinoline
CAS No.:844431-69-2
Molecular Formula:C₂₇H₂₃FN₂O
Molecular Weight:410.491
Hs Code.:

Synonyms:2-(3-fluorophenyl)-6-methoxy-1-[4-pyridin-4-ylphenyl]-1,2,3,4-tetrahydroisoquinoline

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Chemical Property of 2-(3-fluorophenyl)-6-methoxy-1-[4-pyridin-4-ylphenyl]-1,2,3,4-tetrahydroisoquinoline

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Technology Process of 2-(3-fluorophenyl)-6-methoxy-1-[4-pyridin-4-ylphenyl]-1,2,3,4-tetrahydroisoquinoline

There total 5 articles about 2-(3-fluorophenyl)-6-methoxy-1-[4-pyridin-4-ylphenyl]-1,2,3,4-tetrahydroisoquinoline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 74.0%

: 1692-15-5
4-pyridylboronic acid

: 844431-65-8
1-(4-bromophenyl)-2-(3-fluorophenyl)-6-methoxy-1,2,3,4-tetrahydroisoquinoline

: 844431-69-2
2-(3-fluorophenyl)-6-methoxy-1-[4-pyridin-4-ylphenyl]-1,2,3,4-tetrahydroisoquinoline

Guidance literature:: With dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; potassium carbonate; In acetone; toluene; for 42h; Heating;
DOI:10.1021/jm040858p

Reference yield:

: 1121-86-4
1-Fluoro-3-iodobenzene

: 844431-69-2
2-(3-fluorophenyl)-6-methoxy-1-[4-pyridin-4-ylphenyl]-1,2,3,4-tetrahydroisoquinoline

Guidance literature:: Multi-step reaction with 4 steps

1.1: 69 percent / K₂CO₃; CuI / dimethylformamide / 72 h / 150 °C

2.1: n-BuLi / hexane; tetrahydrofuran / 0.42 h / -78 °C

2.2: tetrahydrofuran; hexane / 3 h / -78 °C

3.1: 3.12 g / NaBH₄ / methanol / 0.5 h / 20 °C

4.1: 74 percent / aq. K₂CO₃; PdCl₂(dppf)*CH₂Cl₂ / toluene; acetone / 42 h / Heating

With sodium tetrahydroborate; copper(l) iodide; n-butyllithium; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; potassium carbonate; In tetrahydrofuran; methanol; hexane; N,N-dimethyl-formamide; acetone; toluene; 4.1: Suzuki coupling;
DOI:10.1021/jm040858p

Reference yield:

: 22246-12-4
6-methoxy-1,2,3,4-tetrahydro-1-oxoisoquinoline

: 844431-69-2
2-(3-fluorophenyl)-6-methoxy-1-[4-pyridin-4-ylphenyl]-1,2,3,4-tetrahydroisoquinoline

Guidance literature:: Multi-step reaction with 4 steps

1.1: 69 percent / K₂CO₃; CuI / dimethylformamide / 72 h / 150 °C

2.1: n-BuLi / hexane; tetrahydrofuran / 0.42 h / -78 °C

2.2: tetrahydrofuran; hexane / 3 h / -78 °C

3.1: 3.12 g / NaBH₄ / methanol / 0.5 h / 20 °C

4.1: 74 percent / aq. K₂CO₃; PdCl₂(dppf)*CH₂Cl₂ / toluene; acetone / 42 h / Heating

With sodium tetrahydroborate; copper(l) iodide; n-butyllithium; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; potassium carbonate; In tetrahydrofuran; methanol; hexane; N,N-dimethyl-formamide; acetone; toluene; 4.1: Suzuki coupling;
DOI:10.1021/jm040858p