(S)-2-phenyl-1-(thiazol-2-yl)ethanaMine hydrochloride

Base Information

• Chemical Name: (S)-2-phenyl-1-(thiazol-2-yl)ethanaMine hydrochloride
• CAS No.: 135383-60-7
• Molecular Formula: C₁₁H₁₂N₂S*ClH
• Molecular Weight: 240.757
• Mol file: 135383-60-7.mol

Synonyms:(1S)-2-phenyl-1-(1,3-thiazol-2-yl)ethanamine, hydrochloride salt

Chemical Property of (S)-2-phenyl-1-(thiazol-2-yl)ethanaMine hydrochloride

Chemical Property:

• Storage Temp.: Inert atmosphere,Room Temperature

Purity/Quality:

97% ^*data from raw suppliers

(S)-2-phenyl-1-(thiazol-2-yl)ethanaMinehydrochloride 95 ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of (S)-2-phenyl-1-(thiazol-2-yl)ethanaMine hydrochloride

There total 8 articles about (S)-2-phenyl-1-(thiazol-2-yl)ethanaMine hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

tert-butyl N-[(1S)-2-phenyl-1-(1,3-thiazol-2-yl)ethyl]carbamate (120205-51-8) → (1S)-2-phenyl-1-(1,3-thiazol-2-yl)ethanamine, hydrochloride salt (135383-60-7)

Guidance literature:

With hydrogenchloride; In 1,4-dioxane; for 1.33333h; Ambient temperature;

DOI:10.1016/S0040-4039(00)79932-1

Reference yield:

Boc-L-phenylalaninal (72155-45-4) → (1S)-2-phenyl-1-(1,3-thiazol-2-yl)ethanamine, hydrochloride salt (135383-60-7)

Guidance literature:

Multi-step reaction with 3 steps

1: benzene

2: 19 percent / MnO₂ / dioxane

3: 93 percent / 2.4 N HCl / dioxane / 1.33 h / Ambient temperature

With hydrogenchloride; manganese(IV) oxide; In 1,4-dioxane; benzene;

DOI:10.1016/S0040-4039(00)79932-1

Reference yield:

(S)-N-tert-butoxycarbonyl-2-amino-3-phenylpropanol (66605-57-0) → (1S)-2-phenyl-1-(1,3-thiazol-2-yl)ethanamine, hydrochloride salt (135383-60-7)

Guidance literature:

Multi-step reaction with 4 steps

1: 1) SO₃, pyridine, 2) NEt₃ / 1) DMSO, 2) CH₂Cl₂

2: benzene

3: 19 percent / MnO₂ / dioxane

4: 93 percent / 2.4 N HCl / dioxane / 1.33 h / Ambient temperature

With pyridine; hydrogenchloride; manganese(IV) oxide; sulfur trioxide; triethylamine; In 1,4-dioxane; benzene;

DOI:10.1016/S0040-4039(00)79932-1

upstream raw materials:

tert-butyl N-[(1S)-2-phenyl-1-(1,3-thiazol-2-yl)ethyl]carbamate

Boc-L-phenylalaninal

(S)-N-tert-butoxycarbonyl-2-amino-3-phenylpropanol

(2RS,1'S)-2-<1'-((tert-butoxycarbonyl)amino)-2'-phenylethyl>-1,3-thiazolidine

Downstream raw materials:

tert-butyl (2S)-2-[(1R,2R)-1-methoxy-2-methyl-3-oxo-3-{[(1S)-2-phenyl-1-(1,3-thiazol-2-yl)ethyl]amino}propyl]pyrrolidine-1-carboxylate

(2R,3R,4S)-dolaproine-(S)-dolaphenine

(3R,4S,5S)-Dil-(2R,3R,4S)-Dap-(S)-Doe

Cbz-Dil-Dap-Doe