1-(4-fluorobenzyloxy)-2-methyl-but-3-ene-2-ol

Base Information

Chemical Name:1-(4-fluorobenzyloxy)-2-methyl-but-3-ene-2-ol
CAS No.:1376767-73-5
Molecular Formula:C₁₂H₁₅FO₂
Molecular Weight:210.248
Hs Code.:

Synonyms:1-(4-fluorobenzyloxy)-2-methyl-but-3-ene-2-ol

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 1-(4-fluorobenzyloxy)-2-methyl-but-3-ene-2-ol

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Technology Process of 1-(4-fluorobenzyloxy)-2-methyl-but-3-ene-2-ol

There total 1 articles about 1-(4-fluorobenzyloxy)-2-methyl-but-3-ene-2-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 54.0%

: 79563-72-7,86777-87-9,86832-94-2,24058-88-6
(±)-2-methylbut-3-ene-1,2-diol

: 1376767-73-5
1-(4-fluorobenzyloxy)-2-methyl-but-3-ene-2-ol

Guidance literature:: (±)-2-methylbut-3-ene-1,2-diol; With sodium hydride; In tetrahydrofuran; at -15 ℃; for 0.5h; Inert atmosphere;

4-fluorobenzyl halide; In tetrahydrofuran; at -15 - 25 ℃; Inert atmosphere;
DOI:10.1021/ja302223p

Reference yield:

: 1376767-73-5
1-(4-fluorobenzyloxy)-2-methyl-but-3-ene-2-ol

: 545-06-2
trichloroacetonitrile

: 1376767-77-9
C₁₄H₁₅Cl₃FNO₂

Guidance literature:: 1-(4-fluorobenzyloxy)-2-methyl-but-3-ene-2-ol; With sodium hydride; In tetrahydrofuran; at 0 ℃; for 0.5h; Inert atmosphere;

trichloroacetonitrile; In tetrahydrofuran; at 0 ℃; for 1.5h; Inert atmosphere;
DOI:10.1021/ja302223p

Reference yield:

: 1376767-73-5
1-(4-fluorobenzyloxy)-2-methyl-but-3-ene-2-ol

: 1376767-94-0
C₁₈H₁₉F₂NO

Guidance literature:: Multi-step reaction with 2 steps

1.1: sodium hydride / tetrahydrofuran / 0.5 h / 0 °C / Inert atmosphere

1.2: 1.5 h / 0 °C / Inert atmosphere

2.1: chlorobis(ethylene)rhodium(I) dimer; (1S,4S)-2,5-bis(4-fluorophenyl)bicyclo[2.2.2]octa-2,5-diene / tert-butyl methyl ether / 1 h / 25 °C / Inert atmosphere

With chlorobis(ethylene)rhodium(I) dimer; (1S,4S)-2,5-bis(4-fluorophenyl)bicyclo[2.2.2]octa-2,5-diene; sodium hydride; In tetrahydrofuran; tert-butyl methyl ether;
DOI:10.1021/ja302223p