3-(4-cyclopropylphenoxy)-1-(3-(difluoromethoxy)-4-(2-hydroxyethoxy)phenyl)-1H-pyrrol-2(5H)-one

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Chemical Name:3-(4-cyclopropylphenoxy)-1-(3-(difluoromethoxy)-4-(2-hydroxyethoxy)phenyl)-1H-pyrrol-2(5H)-one
CAS No.:1574541-99-3
Molecular Formula:C₂₂H₂₁F₂NO₅
Molecular Weight:417.409
Hs Code.:

Synonyms:3-(4-cyclopropylphenoxy)-1-(3-(difluoromethoxy)-4-(2-hydroxyethoxy)phenyl)-1H-pyrrol-2(5H)-one

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Chemical Property of 3-(4-cyclopropylphenoxy)-1-(3-(difluoromethoxy)-4-(2-hydroxyethoxy)phenyl)-1H-pyrrol-2(5H)-one

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Technology Process of 3-(4-cyclopropylphenoxy)-1-(3-(difluoromethoxy)-4-(2-hydroxyethoxy)phenyl)-1H-pyrrol-2(5H)-one

There total 10 articles about 3-(4-cyclopropylphenoxy)-1-(3-(difluoromethoxy)-4-(2-hydroxyethoxy)phenyl)-1H-pyrrol-2(5H)-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1574541-98-2
1-(4-(2-((tert-butyldimethylsilyl)oxy)ethoxy)-3-(difluoromethoxy)phenyl)-(4-cyclopropylphenoxy)-1H-pyrrol-2(5H)-one

: 1574541-99-3
3-(4-cyclopropylphenoxy)-1-(3-(difluoromethoxy)-4-(2-hydroxyethoxy)phenyl)-1H-pyrrol-2(5H)-one

Guidance literature:: With hydrogenchloride; In tetrahydrofuran; water; at 20 ℃; for 3h;

Reference yield:

: 1574541-77-7
methyl 2-(4-cyclopropylphenoxy)but-2-enoate

: 1574541-99-3
3-(4-cyclopropylphenoxy)-1-(3-(difluoromethoxy)-4-(2-hydroxyethoxy)phenyl)-1H-pyrrol-2(5H)-one

Guidance literature:: Multi-step reaction with 5 steps

1: lithium hydroxide monohydrate; water / tetrahydrofuran / 0 - 20 °C

2: triethylamine; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / acetonitrile / 16 h

3: sodium hydride / N,N-dimethyl-formamide / 0.5 h / 0 °C

4: tricyclohexylphosphine[1,3-bis(2,4,6-trimethylphenyl)-4,5-dihydroimidazol-2-ylidine][benzylidene]ruthenium(II) dichloride / toluene / 24 h / 80 °C

5: hydrogenchloride / water; tetrahydrofuran / 3 h / 20 °C

With tricyclohexylphosphine[1,3-bis(2,4,6-trimethylphenyl)-4,5-dihydroimidazol-2-ylidine][benzylidene]ruthenium(II) dichloride; hydrogenchloride; lithium hydroxide monohydrate; water; sodium hydride; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; In tetrahydrofuran; water; N,N-dimethyl-formamide; toluene; acetonitrile;

Reference yield:

: 1574541-78-8
2-(4-cyclopropylphenoxy)but-2-enoic acid

: 1574541-99-3
3-(4-cyclopropylphenoxy)-1-(3-(difluoromethoxy)-4-(2-hydroxyethoxy)phenyl)-1H-pyrrol-2(5H)-one

Guidance literature:: Multi-step reaction with 4 steps

1: triethylamine; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / acetonitrile / 16 h

2: sodium hydride / N,N-dimethyl-formamide / 0.5 h / 0 °C

3: tricyclohexylphosphine[1,3-bis(2,4,6-trimethylphenyl)-4,5-dihydroimidazol-2-ylidine][benzylidene]ruthenium(II) dichloride / toluene / 24 h / 80 °C

4: hydrogenchloride / water; tetrahydrofuran / 3 h / 20 °C

With tricyclohexylphosphine[1,3-bis(2,4,6-trimethylphenyl)-4,5-dihydroimidazol-2-ylidine][benzylidene]ruthenium(II) dichloride; hydrogenchloride; sodium hydride; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; In tetrahydrofuran; water; N,N-dimethyl-formamide; toluene; acetonitrile;