2-methylthio-(E,E)-4,6-bis-(4'-hydroxy-3'-N,N-dimethylaminostyryl)pyrimidine

Base Information

Chemical Name:2-methylthio-(E,E)-4,6-bis-(4'-hydroxy-3'-N,N-dimethylaminostyryl)pyrimidine
CAS No.:1236355-48-8
Molecular Formula:C₂₅H₂₈N₄O₂S
Molecular Weight:448.589
Hs Code.:

Synonyms:2-methylthio-(E,E)-4,6-bis-(4'-hydroxy-3'-N,N-dimethylaminostyryl)pyrimidine

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 2-methylthio-(E,E)-4,6-bis-(4'-hydroxy-3'-N,N-dimethylaminostyryl)pyrimidine

Chemical Property:

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Technology Process of 2-methylthio-(E,E)-4,6-bis-(4'-hydroxy-3'-N,N-dimethylaminostyryl)pyrimidine

There total 6 articles about 2-methylthio-(E,E)-4,6-bis-(4'-hydroxy-3'-N,N-dimethylaminostyryl)pyrimidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 42.0%

: 1396037-29-8
2-methylthio-(E,E)-4,6-bis(4'-methoxymethoxy-3'-N,N-dimethylaminostyryl)pyrimidine

: 1236355-48-8
2-methylthio-(E,E)-4,6-bis-(4'-hydroxy-3'-N,N-dimethylaminostyryl)pyrimidine

Guidance literature:: With hydrogenchloride; In ethanol; water; Reflux;
DOI:10.1016/j.bmc.2012.06.045

Reference yield:

: 123-54-6,81235-32-7
acetylacetone

: 1236355-48-8
2-methylthio-(E,E)-4,6-bis-(4'-hydroxy-3'-N,N-dimethylaminostyryl)pyrimidine

Guidance literature:: Multi-step reaction with 3 steps

1: potassium carbonate / water / 25 °C / Reflux

2: tetra(n-butyl)ammonium hydrogensulfate; sodium hydroxide / water / Reflux

3: hydrogenchloride / ethanol; water / Reflux

With hydrogenchloride; tetra(n-butyl)ammonium hydrogensulfate; potassium carbonate; sodium hydroxide; In ethanol; water;
DOI:10.1016/j.bmc.2012.06.045

Reference yield:

: 1396038-68-8
N,N-3-(dimethylamino)-4-(methoxymethyl)benzoic acid methyl ester

: 1236355-48-8
2-methylthio-(E,E)-4,6-bis-(4'-hydroxy-3'-N,N-dimethylaminostyryl)pyrimidine

Guidance literature:: Multi-step reaction with 4 steps

1.1: lithium aluminium tetrahydride / tetrahydrofuran / 1 h / 0 °C

1.2: 1 h / 20 °C

2.1: manganese(IV) oxide / dichloromethane / Reflux

3.1: tetra(n-butyl)ammonium hydrogensulfate; sodium hydroxide / water / Reflux

4.1: hydrogenchloride / ethanol; water / Reflux

With hydrogenchloride; manganese(IV) oxide; lithium aluminium tetrahydride; tetra(n-butyl)ammonium hydrogensulfate; sodium hydroxide; In tetrahydrofuran; ethanol; dichloromethane; water;
DOI:10.1016/j.bmc.2012.06.045