5-fluoro-1-(2-fluorobenzyl)-1H-pyrazolo[3,4-b]pyridine-3-carboximidamide acetic acid

Base Information

• Chemical Name: 5-fluoro-1-(2-fluorobenzyl)-1H-pyrazolo[3,4-b]pyridine-3-carboximidamide acetic acid
• CAS No.: 1350653-28-9
• Molecular Formula: C₂H₄O₂*C₁₄H₁₁F₂N₅
• Molecular Weight: 347.324
• Mol file: 1350653-28-9.mol

Synonyms:5-fluoro-1-(2-fluorobenzyl)-1H-pyrazolo[3,4-b]pyridine-3-carboximidamide acetic acid

Chemical Property of 5-fluoro-1-(2-fluorobenzyl)-1H-pyrazolo[3,4-b]pyridine-3-carboximidamide acetic acid

Chemical Property:

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 5-fluoro-1-(2-fluorobenzyl)-1H-pyrazolo[3,4-b]pyridine-3-carboximidamide acetic acid

There total 3 articles about 5-fluoro-1-(2-fluorobenzyl)-1H-pyrazolo[3,4-b]pyridine-3-carboximidamide acetic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

ethyl 5-amino-1-(2-fluorobenzyl)-1H-pyrazole-3-carboxylate (256504-39-9) → 5-fluoro-1-(2-fluorobenzyl)-1H-pyrazolo[3,4-b]pyridine-3-carboximidamide acetic acid (1350653-28-9)

Guidance literature:

Multi-step reaction with 4 steps

1.1: trifluoroacetic acid / 1,4-dioxane / 72 h / 20 °C / Reflux

2.1: ammonia / methanol

3.1: pyridine; trifluoroacetic anhydride / tetrahydrofuran / 20 °C

4.1: sodium methylate / methanol / 2 h / 20 °C

4.2: Reflux

With pyridine; ammonia; sodium methylate; trifluoroacetic acid; trifluoroacetic anhydride; In tetrahydrofuran; 1,4-dioxane; methanol;

Reference yield:

ethyl 5-fluoro-1-(2-fluorobenzyl)-1H-pyrazolo[3,4-b]pyridine-3-carboxylate (1361232-72-5) → 5-fluoro-1-(2-fluorobenzyl)-1H-pyrazolo[3,4-b]pyridine-3-carboximidamide acetic acid (1350653-28-9)

Guidance literature:

Multi-step reaction with 3 steps

1.1: ammonia / methanol

2.1: pyridine; trifluoroacetic anhydride / tetrahydrofuran / 20 °C

3.1: sodium methylate / methanol / 2 h / 20 °C

3.2: Reflux

With pyridine; ammonia; sodium methylate; trifluoroacetic anhydride; In tetrahydrofuran; methanol;

Reference yield:

5-fluoro-1-(2-fluorobenzyl)-1H-pyrazolo[3,4-b]pyridine-3-carboxamide (1361232-73-6) → 5-fluoro-1-(2-fluorobenzyl)-1H-pyrazolo[3,4-b]pyridine-3-carboximidamide acetic acid (1350653-28-9)

Guidance literature:

Multi-step reaction with 2 steps

1.1: pyridine; trifluoroacetic anhydride / tetrahydrofuran / 20 °C

2.1: sodium methylate / methanol / 2 h / 20 °C

2.2: Reflux

With pyridine; sodium methylate; trifluoroacetic anhydride; In tetrahydrofuran; methanol;

upstream raw materials:

ethyl 5-amino-1-(2-fluorobenzyl)-1H-pyrazole-3-carboxylate

ethyl 5-fluoro-1-(2-fluorobenzyl)-1H-pyrazolo[3,4-b]pyridine-3-carboxylate

5-fluoro-1-(2-fluorobenzyl)-1H-pyrazolo[3,4-b]pyridine-3-carboxamide

Downstream raw materials:

2-[5-fluoro-1-(2-fluorobenzyl)-1H-pyrazolo[3,4-b]pyridin-3-yl]pyrimidine-4,5,6-triamine

methyl {4,6-diamino-2-[5-fluoro-1-(2-fluorobenzyl)-1H-pyrazolo[3,4-b]pyridine-3-yl]pyrimidin-5-yl}carbamate

methyl {4,6-diamino-2-[5-fluoro-1-(2-fluorobenzyl)-1H-pyrazolo[3,4-b]pyridin-3-yl]pyrimidin-5-yl}(2,2,2-trifluoroethyl)carbamate

3-(4-chloro-5-nitropyrimidin-2-yl)-5-fluoro-1-(2-fluorobenzyl)-1H-pyrazolo [3,4-b]pyridine