methyl 2-chloro-4-[[3-(2,6-dichlorophenyl)-5-isopropyl-isoxazol-4-yl]methoxy]benzoate

Base Information

• Chemical Name: methyl 2-chloro-4-[[3-(2,6-dichlorophenyl)-5-isopropyl-isoxazol-4-yl]methoxy]benzoate
• CAS No.: 1573119-83-1
• Molecular Formula: C₂₁H₁₈Cl₃NO₄
• Molecular Weight: 454.737

Synonyms:methyl 2-chloro-4-[[3-(2,6-dichlorophenyl)-5-isopropyl-isoxazol-4-yl]methoxy]benzoate

Chemical Property of methyl 2-chloro-4-[[3-(2,6-dichlorophenyl)-5-isopropyl-isoxazol-4-yl]methoxy]benzoate

Chemical Property:

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Technology Process of methyl 2-chloro-4-[[3-(2,6-dichlorophenyl)-5-isopropyl-isoxazol-4-yl]methoxy]benzoate

There total 4 articles about methyl 2-chloro-4-[[3-(2,6-dichlorophenyl)-5-isopropyl-isoxazol-4-yl]methoxy]benzoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

4-(bromomethyl)-3-(2,6-dichlorophenyl)-5-isopropyl-isoxazole (898253-47-9) + methyl 2-chloro-4-hydroxy-benzoate (104253-44-3) → methyl 2-chloro-4-[[3-(2,6-dichlorophenyl)-5-isopropyl-isoxazol-4-yl]methoxy]benzoate (1573119-83-1)

Guidance literature:

With potassium carbonate; In N,N-dimethyl-formamide; at 70 ℃; for 15h;

DOI:10.3390/molecules24224155

Reference yield:

2-chloro-4-hydroxybenzonitrile (3336-16-1) → methyl 2-chloro-4-[[3-(2,6-dichlorophenyl)-5-isopropyl-isoxazol-4-yl]methoxy]benzoate (1573119-83-1)

Guidance literature:

Multi-step reaction with 3 steps

1: potassium hydroxide / ethanol / 48 h / Reflux

2: sulfuric acid / 48 h

3: triphenylphosphine; di-isopropyl azodicarboxylate / tetrahydrofuran / 0 - 20 °C / Inert atmosphere

With di-isopropyl azodicarboxylate; sulfuric acid; triphenylphosphine; potassium hydroxide; In tetrahydrofuran; ethanol;

DOI:10.1002/cmdc.201300305

Reference yield:

2-chloro-4-hydroxybenzoic acid (56363-84-9) → methyl 2-chloro-4-[[3-(2,6-dichlorophenyl)-5-isopropyl-isoxazol-4-yl]methoxy]benzoate (1573119-83-1)

Guidance literature:

Multi-step reaction with 2 steps

1: sulfuric acid / 48 h

2: triphenylphosphine; di-isopropyl azodicarboxylate / tetrahydrofuran / 0 - 20 °C / Inert atmosphere

With di-isopropyl azodicarboxylate; sulfuric acid; triphenylphosphine; In tetrahydrofuran;

DOI:10.1002/cmdc.201300305

upstream raw materials:

2-chloro-4-hydroxybenzonitrile

2-chloro-4-hydroxybenzoic acid

methyl 3-(2,6-dichlorophenyl)-5-(propan-2-yl)-1,2-oxazole-4-carboxylate

4-(bromomethyl)-3-(2,6-dichlorophenyl)-5-isopropyl-isoxazole

Downstream raw materials:

2-chloro-4-{[5-isopropyl-3-(2,6-dichlorophenyl)-isoxazol-4-yl]methoxy}benzoic acid

methyl 4-{[2-chloro-4-[[3-(2,6-dichlorophenyl)-5-isopropyl-isoxazol-4-yl]methoxy]benzoyl]amino}benzoate

4-{[2-chloro-4-[[3-(2,6-dichlorophenyl)-5-isopropyl-isoxazol-4-yl]methoxy]benzoyl]amino}benzoic acid

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