tert-butyl 2-(6-bromo-4-oxo-3,4-dihydrothieno[3,2-d]pyrimidin-2-yl)-4-hydroxy-4-phenylpyrrolidine-1-carboxylate

Base Information

Chemical Name:tert-butyl 2-(6-bromo-4-oxo-3,4-dihydrothieno[3,2-d]pyrimidin-2-yl)-4-hydroxy-4-phenylpyrrolidine-1-carboxylate
CAS No.:1330784-41-2
Molecular Formula:C₂₁H₂₂BrN₃O₄S
Molecular Weight:492.393
Hs Code.:

Synonyms:tert-butyl 2-(6-bromo-4-oxo-3,4-dihydrothieno[3,2-d]pyrimidin-2-yl)-4-hydroxy-4-phenylpyrrolidine-1-carboxylate

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Chemical Property of tert-butyl 2-(6-bromo-4-oxo-3,4-dihydrothieno[3,2-d]pyrimidin-2-yl)-4-hydroxy-4-phenylpyrrolidine-1-carboxylate

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Technology Process of tert-butyl 2-(6-bromo-4-oxo-3,4-dihydrothieno[3,2-d]pyrimidin-2-yl)-4-hydroxy-4-phenylpyrrolidine-1-carboxylate

There total 7 articles about tert-butyl 2-(6-bromo-4-oxo-3,4-dihydrothieno[3,2-d]pyrimidin-2-yl)-4-hydroxy-4-phenylpyrrolidine-1-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1330784-43-4
tert-butyl 2-[(5-bromo-2-carbamoylthiophen-3-yl)carbamoyl]-4-hydroxy-4-phenylpyrrolidine-1-carboxylate

: 1330784-41-2
tert-butyl 2-(6-bromo-4-oxo-3,4-dihydrothieno[3,2-d]pyrimidin-2-yl)-4-hydroxy-4-phenylpyrrolidine-1-carboxylate

Guidance literature:: tert-butyl 2-[(5-bromo-2-carbamoylthiophen-3-yl)carbamoyl]-4-hydroxy-4-phenylpyrrolidine-1-carboxylate; With sodium hydroxide; In ethanol; water; at 70 ℃; for 3h;

With hydrogenchloride; In ethanol; water; Cooling with ice;

Reference yield:

: 107818-55-3
3-amino-5-bromo-thiophene-2-carboxylic acid methyl ester

: 1330784-41-2
tert-butyl 2-(6-bromo-4-oxo-3,4-dihydrothieno[3,2-d]pyrimidin-2-yl)-4-hydroxy-4-phenylpyrrolidine-1-carboxylate

Guidance literature:: Multi-step reaction with 3 steps

1.1: lithium hexamethyldisilazane / tetrahydrofuran / 0.5 h / 0 °C

1.2: 15 h / 20 °C

2.1: sodium hydroxide / ethanol; water / 2 h / 60 °C

2.3: 15 h / 20 °C

3.1: sodium hydroxide / ethanol; water / 3 h / 70 °C

3.2: Cooling with ice

With sodium hydroxide; lithium hexamethyldisilazane; In tetrahydrofuran; ethanol; water;

Reference yield:

: 79128-68-0
methyl 3-(2,2,2-trifluoroacetamido)thiophene-2-carboxylate

: 1330784-41-2
tert-butyl 2-(6-bromo-4-oxo-3,4-dihydrothieno[3,2-d]pyrimidin-2-yl)-4-hydroxy-4-phenylpyrrolidine-1-carboxylate

Guidance literature:: Multi-step reaction with 5 steps

1.1: diisopropylamine; n-butyllithium / hexane; tetrahydrofuran / 1 h / -78 °C

1.2: 1 h / -78 - 20 °C

2.1: potassium carbonate; methanol / water / 2 h / 20 °C

3.1: lithium hexamethyldisilazane / tetrahydrofuran / 0.5 h / 0 °C

3.2: 15 h / 20 °C

4.1: sodium hydroxide / ethanol; water / 2 h / 60 °C

4.3: 15 h / 20 °C

5.1: sodium hydroxide / ethanol; water / 3 h / 70 °C

5.2: Cooling with ice

With methanol; n-butyllithium; potassium carbonate; diisopropylamine; sodium hydroxide; lithium hexamethyldisilazane; In tetrahydrofuran; ethanol; hexane; water;