N-(Cyclohexylmethyl)-N-[(9H-fluoren-9-ylmethoxy)carbonyl]-L-alanine

Base Information

Chemical Name:N-(Cyclohexylmethyl)-N-[(9H-fluoren-9-ylmethoxy)carbonyl]-L-alanine
CAS No.:84000-08-8
Molecular Formula:C₂₅H₂₉NO₄
Molecular Weight:407.51
Hs Code.:
DSSTox Substance ID:DTXSID001162491

Synonyms:DTXSID001162491;N-(Cyclohexylmethyl)-N-[(9H-fluoren-9-ylmethoxy)carbonyl]-L-alanine;84000-08-8

Suppliers and Price of N-(Cyclohexylmethyl)-N-[(9H-fluoren-9-ylmethoxy)carbonyl]-L-alanine

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of N-(Cyclohexylmethyl)-N-[(9H-fluoren-9-ylmethoxy)carbonyl]-L-alanine

Chemical Property:

XLogP3:5.6
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:7
Exact Mass:407.20965841
Heavy Atom Count:30
Complexity:580

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:CC(C(=O)O)N(CC1CCCCC1)C(=O)OCC2C3=CC=CC=C3C4=CC=CC=C24
Isomeric SMILES:C[C@@H](C(=O)O)N(CC1CCCCC1)C(=O)OCC2C3=CC=CC=C3C4=CC=CC=C24

Technology Process of N-(Cyclohexylmethyl)-N-[(9H-fluoren-9-ylmethoxy)carbonyl]-L-alanine

There total 3 articles about N-(Cyclohexylmethyl)-N-[(9H-fluoren-9-ylmethoxy)carbonyl]-L-alanine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

: 83999-96-6,83999-97-7,99612-46-1
(2RS,4S)-2-cyclohexyl-3-(9-fluorenylmethyloxycarbonyl)-4-methyl-5-oxooxazolidine

: 84000-08-8
N-(cyclohexylmethyl)-N-Fmoc-L-alanine

Guidance literature:: With triethylsilane; trifluoroacetic acid; In chloroform; for 22h; Ambient temperature;
DOI:10.1021/jo00149a016

Reference yield:

: 35661-39-3,136132-75-7
N-[(9H-fluoren-9-ylmethoxy)carbonyl]-L-alanine

: 84000-08-8
N-(cyclohexylmethyl)-N-Fmoc-L-alanine

Guidance literature:: Multi-step reaction with 2 steps

1: 77 percent / p-toluenesulfonic acid / toluene / 7 h / Heating

2: 91 percent / trifluoroacetic acid, triethylsilane / CHCl₃ / 22 h / Ambient temperature

With triethylsilane; toluene-4-sulfonic acid; trifluoroacetic acid; In chloroform; toluene;
DOI:10.1021/jo00149a016

Reference yield:

: 2043-61-0
cyclohexanecarbaldehyde

: 84000-08-8
N-(cyclohexylmethyl)-N-Fmoc-L-alanine

Guidance literature:: Multi-step reaction with 2 steps

1: 77 percent / p-toluenesulfonic acid / toluene / 7 h / Heating

2: 91 percent / trifluoroacetic acid, triethylsilane / CHCl₃ / 22 h / Ambient temperature

With triethylsilane; toluene-4-sulfonic acid; trifluoroacetic acid; In chloroform; toluene;
DOI:10.1021/jo00149a016