4,4-Bis-(diethoxy-phosphoryl)-2-{4-[methyl-(2,2,2-trichloro-ethoxycarbonyl)-amino]-benzoylamino}-butyric acid ethyl ester

Base Information

Chemical Name:4,4-Bis-(diethoxy-phosphoryl)-2-{4-[methyl-(2,2,2-trichloro-ethoxycarbonyl)-amino]-benzoylamino}-butyric acid ethyl ester
CAS No.:120355-33-1
Molecular Formula:C₂₅H₃₉Cl₃N₂O₁₁P₂
Molecular Weight:711.898
Hs Code.:

Synonyms:4,4-Bis-(diethoxy-phosphoryl)-2-{4-[methyl-(2,2,2-trichloro-ethoxycarbonyl)-amino]-benzoylamino}-butyric acid ethyl ester

Suppliers and Price of 4,4-Bis-(diethoxy-phosphoryl)-2-{4-[methyl-(2,2,2-trichloro-ethoxycarbonyl)-amino]-benzoylamino}-butyric acid ethyl ester

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of 4,4-Bis-(diethoxy-phosphoryl)-2-{4-[methyl-(2,2,2-trichloro-ethoxycarbonyl)-amino]-benzoylamino}-butyric acid ethyl ester

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of 4,4-Bis-(diethoxy-phosphoryl)-2-{4-[methyl-(2,2,2-trichloro-ethoxycarbonyl)-amino]-benzoylamino}-butyric acid ethyl ester

There total 1 articles about 4,4-Bis-(diethoxy-phosphoryl)-2-{4-[methyl-(2,2,2-trichloro-ethoxycarbonyl)-amino]-benzoylamino}-butyric acid ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.0%

: 120355-30-8
2-amino-4,4-bis(diethylphosphono)butanoic acid ethyl ester

: (4-Chlorocarbonyl-phenyl)-methyl-carbamic acid 2,2,2-trichloro-ethyl ester

: 120355-33-1
4,4-Bis-(diethoxy-phosphoryl)-2-{4-[methyl-(2,2,2-trichloro-ethoxycarbonyl)-amino]-benzoylamino}-butyric acid ethyl ester

Guidance literature:: With triethylamine; In tetrahydrofuran; for 1h; Ambient temperature;
DOI:10.1016/0223-5234(92)90117-J

Reference yield:

: 120355-33-1
4,4-Bis-(diethoxy-phosphoryl)-2-{4-[methyl-(2,2,2-trichloro-ethoxycarbonyl)-amino]-benzoylamino}-butyric acid ethyl ester

: 120355-34-2
tetraethyl 3-ethoxycarbonyl-N-<4-(methylamino)benzoyl>-3-aminopropylidene-1,1-bisphosphonate

Guidance literature:: With potassium dihydrogenphosphate; zinc; In tetrahydrofuran; water; for 24h; Yield given; Ambient temperature;
DOI:10.1016/0223-5234(92)90117-J

Reference yield:

: 120355-33-1
4,4-Bis-(diethoxy-phosphoryl)-2-{4-[methyl-(2,2,2-trichloro-ethoxycarbonyl)-amino]-benzoylamino}-butyric acid ethyl ester

: 2-{4-[(2,4-Diamino-pteridin-6-ylmethyl)-methyl-amino]-benzoylamino}-4,4-bis-phosphono-butyric acid

Guidance literature:: Multi-step reaction with 3 steps

1: KH₂PO₄, Zn / H₂O; tetrahydrofuran / 24 h / Ambient temperature

2: 68 percent / N,N-dimethyl-acetamide / 4 h / 50 °C

3: 1.) trimethylsilyl bromide, 2.) CH₃OH / 1.) CH₂Cl₂, RT, 48 h, 2.) RT, 30 min

With methanol; potassium dihydrogenphosphate; trimethylsilyl bromide; zinc; In tetrahydrofuran; N,N-dimethyl acetamide; water;
DOI:10.1016/0223-5234(92)90117-J