N-[2-{[4-hydroxymethyl-2,6-dimethylbenzyl]oxy}-4-(trifluoromethyl)phenyl]-N-isobutyl-5-methylfuran-2-sulfonamide

Base Information

Chemical Name:N-[2-{[4-hydroxymethyl-2,6-dimethylbenzyl]oxy}-4-(trifluoromethyl)phenyl]-N-isobutyl-5-methylfuran-2-sulfonamide
CAS No.:916913-50-3
Molecular Formula:C₂₆H₃₀F₃NO₅S
Molecular Weight:525.589
Hs Code.:

Synonyms:N-[2-{[4-hydroxymethyl-2,6-dimethylbenzyl]oxy}-4-(trifluoromethyl)phenyl]-N-isobutyl-5-methylfuran-2-sulfonamide

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Chemical Property of N-[2-{[4-hydroxymethyl-2,6-dimethylbenzyl]oxy}-4-(trifluoromethyl)phenyl]-N-isobutyl-5-methylfuran-2-sulfonamide

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Technology Process of N-[2-{[4-hydroxymethyl-2,6-dimethylbenzyl]oxy}-4-(trifluoromethyl)phenyl]-N-isobutyl-5-methylfuran-2-sulfonamide

There total 8 articles about N-[2-{[4-hydroxymethyl-2,6-dimethylbenzyl]oxy}-4-(trifluoromethyl)phenyl]-N-isobutyl-5-methylfuran-2-sulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 24.0%

: N-isobutyl-N-[2-({4-(methoxymethoxy)methyl-2,6-dimethylbenzyl}oxy)-4-(trifluoromethyl)phenyl]-5-methylfuran-2-sulfonamide

: 916913-50-3
N-[2-{[4-hydroxymethyl-2,6-dimethylbenzyl]oxy}-4-(trifluoromethyl)phenyl]-N-isobutyl-5-methylfuran-2-sulfonamide

Guidance literature:: With hydrogenchloride; In 1,4-dioxane; water; at 40 ℃; for 3h;
DOI:10.1016/j.bmc.2006.08.001

Reference yield:

: 4-[(methoxymethoxy)methyl]-2,6-dimethylphenol

: 916913-50-3
N-[2-{[4-hydroxymethyl-2,6-dimethylbenzyl]oxy}-4-(trifluoromethyl)phenyl]-N-isobutyl-5-methylfuran-2-sulfonamide

Guidance literature:: Multi-step reaction with 5 steps

1: pyridine / CH₂Cl₂ / 4 h / 20 °C

2: triethylamine; dppf / Pd(OAc)2 / dimethylsulfoxide / 2 h / 70 °C

3: 53 percent / lithium aluminum hydride / tetrahydrofuran / 0.5 h / 0 °C

4: 100 percent / PPh₃; diethyl azodicarboxylate / tetrahydrofuran; toluene / 20 °C

5: 24 percent / hydrochloric acid / H₂O; dioxane / 3 h / 40 °C

With pyridine; hydrogenchloride; 1,1'-bis-(diphenylphosphino)ferrocene; lithium aluminium tetrahydride; triethylamine; triphenylphosphine; diethylazodicarboxylate; palladium diacetate; In tetrahydrofuran; 1,4-dioxane; dichloromethane; water; dimethyl sulfoxide; toluene; 4: Mitsunobu reaction;
DOI:10.1016/j.bmc.2006.08.001

Reference yield:

: trifluoro-methanesulfonic acid 4-methoxymethoxymethyl-2,6-dimethyl-phenyl ester

: 916913-50-3
N-[2-{[4-hydroxymethyl-2,6-dimethylbenzyl]oxy}-4-(trifluoromethyl)phenyl]-N-isobutyl-5-methylfuran-2-sulfonamide

Guidance literature:: Multi-step reaction with 4 steps

1: triethylamine; dppf / Pd(OAc)2 / dimethylsulfoxide / 2 h / 70 °C

2: 53 percent / lithium aluminum hydride / tetrahydrofuran / 0.5 h / 0 °C

3: 100 percent / PPh₃; diethyl azodicarboxylate / tetrahydrofuran; toluene / 20 °C

4: 24 percent / hydrochloric acid / H₂O; dioxane / 3 h / 40 °C

With hydrogenchloride; 1,1'-bis-(diphenylphosphino)ferrocene; lithium aluminium tetrahydride; triethylamine; triphenylphosphine; diethylazodicarboxylate; palladium diacetate; In tetrahydrofuran; 1,4-dioxane; water; dimethyl sulfoxide; toluene; 3: Mitsunobu reaction;
DOI:10.1016/j.bmc.2006.08.001