(R)-benzyl 3-(2-((tert-butoxycarbonyl)amino)-3-methoxy-3-oxopropyl)-1H-indole-1-carboxylate

Base Information

Chemical Name:(R)-benzyl 3-(2-((tert-butoxycarbonyl)amino)-3-methoxy-3-oxopropyl)-1H-indole-1-carboxylate
CAS No.:1352575-55-3
Molecular Formula:C₂₅H₂₈N₂O₆
Molecular Weight:452.507
Hs Code.:

Synonyms:(R)-benzyl 3-(2-((tert-butoxycarbonyl)amino)-3-methoxy-3-oxopropyl)-1H-indole-1-carboxylate

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (R)-benzyl 3-(2-((tert-butoxycarbonyl)amino)-3-methoxy-3-oxopropyl)-1H-indole-1-carboxylate

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Technology Process of (R)-benzyl 3-(2-((tert-butoxycarbonyl)amino)-3-methoxy-3-oxopropyl)-1H-indole-1-carboxylate

There total 1 articles about (R)-benzyl 3-(2-((tert-butoxycarbonyl)amino)-3-methoxy-3-oxopropyl)-1H-indole-1-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

: 501-53-1,94274-21-2
benzyl chloroformate

: 151872-21-8
(R)-2-tert-butoxycarbonylamino-3-(1H-indol-3-yl)-propionic acid methyl ester

: 1352575-55-3
(R)-benzyl 3-(2-((tert-butoxycarbonyl)amino)-3-methoxy-3-oxopropyl)-1H-indole-1-carboxylate

Guidance literature:: With tetra(n-butyl)ammonium hydrogensulfate; sodium hydroxide; In dichloromethane; at 23 ℃; for 4h; Inert atmosphere;
DOI:10.1002/anie.201103145

Reference yield: 91.0%

: 1352575-55-3
(R)-benzyl 3-(2-((tert-butoxycarbonyl)amino)-3-methoxy-3-oxopropyl)-1H-indole-1-carboxylate

: 1352575-47-3
(2R,3aS,8aS)-8-benzyl 1-tert-butyl 2-methyl 3a-bromo-3,3a-dihydropyrrolo[2,3-b]indole-1,2,8(2H,8aH)-tricarboxylate

Guidance literature:: With N-Bromosuccinimide; pyridinium p-toluenesulfonate; In dichloromethane; at 23 ℃; for 12h; Inert atmosphere;
DOI:10.1002/anie.201103145

Reference yield:

: 1352575-55-3
(R)-benzyl 3-(2-((tert-butoxycarbonyl)amino)-3-methoxy-3-oxopropyl)-1H-indole-1-carboxylate

: 1352575-48-4
(2R,3aS,8aS)-8-benzyl 1-tert-butyl 3a-bromo-2-(methylcarbamoyl)-3,3a-dihydropyrrolo[2,3-b]indole-1,8(2H,8aH)-dicarboxylate

Guidance literature:: Multi-step reaction with 2 steps

1: N-Bromosuccinimide; pyridinium p-toluenesulfonate / dichloromethane / 12 h / 23 °C / Inert atmosphere

2: tetrahydrofuran; water / 96 h / 23 °C / Inert atmosphere

With N-Bromosuccinimide; pyridinium p-toluenesulfonate; In tetrahydrofuran; dichloromethane; water;
DOI:10.1002/anie.201103145