{3-[5-(3-chloro-4-fluoro-benzyl)-8-hydroxy-5-methyl-6-oxo-5,6-dihydro-indolizin-7-yl]-1,1-dioxo-1,4-dihydro-1λ6-benzo[1,2,4]thiadiazin-7-yl}-carbamic acid tert-butyl ester

Base Information

Chemical Name:{3-[5-(3-chloro-4-fluoro-benzyl)-8-hydroxy-5-methyl-6-oxo-5,6-dihydro-indolizin-7-yl]-1,1-dioxo-1,4-dihydro-1λ6-benzo[1,2,4]thiadiazin-7-yl}-carbamic acid tert-butyl ester
CAS No.:1056901-39-3
Molecular Formula:C₂₈H₂₆ClFN₄O₆S
Molecular Weight:601.055
Hs Code.:

{3-[5-(3-chloro-4-fluoro-benzyl)-8-hydroxy-5-methyl-6-oxo-5,6-dihydro-indolizin-7-yl]-1,1-dioxo-1,4-dihydro-1λ<SP>6</SP>-benzo[1,2,4]thiadiazin-7-yl}-carbamic acid tert-butyl ester

Synonyms:{3-[5-(3-chloro-4-fluoro-benzyl)-8-hydroxy-5-methyl-6-oxo-5,6-dihydro-indolizin-7-yl]-1,1-dioxo-1,4-dihydro-1λ6-benzo[1,2,4]thiadiazin-7-yl}-carbamic acid tert-butyl ester

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Chemical Property of {3-[5-(3-chloro-4-fluoro-benzyl)-8-hydroxy-5-methyl-6-oxo-5,6-dihydro-indolizin-7-yl]-1,1-dioxo-1,4-dihydro-1λ6-benzo[1,2,4]thiadiazin-7-yl}-carbamic acid tert-butyl ester

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Technology Process of {3-[5-(3-chloro-4-fluoro-benzyl)-8-hydroxy-5-methyl-6-oxo-5,6-dihydro-indolizin-7-yl]-1,1-dioxo-1,4-dihydro-1λ6-benzo[1,2,4]thiadiazin-7-yl}-carbamic acid tert-butyl ester

There total 10 articles about {3-[5-(3-chloro-4-fluoro-benzyl)-8-hydroxy-5-methyl-6-oxo-5,6-dihydro-indolizin-7-yl]-1,1-dioxo-1,4-dihydro-1λ6-benzo[1,2,4]thiadiazin-7-yl}-carbamic acid tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 65.0%

: 691361-59-8
(4-amino-3-sulfamoyl-phenyl)carbamic acid tert-butyl ester

: 1056901-41-7
5-(3-chloro-4-fluoro-benzyl)-8-hydroxy-5-methyl-6-oxo-5,6-dihydro-indolizine-7-carboxylic acid methyl ester

: 1056901-39-3
{3-[5-(3-chloro-4-fluoro-benzyl)-8-hydroxy-5-methyl-6-oxo-5,6-dihydro-indolizin-7-yl]-1,1-dioxo-1,4-dihydro-1λ6-benzo[1,2,4]thiadiazin-7-yl}-carbamic acid tert-butyl ester

Guidance literature:: (4-amino-3-sulfamoyl-phenyl)carbamic acid tert-butyl ester; 5-(3-chloro-4-fluoro-benzyl)-8-hydroxy-5-methyl-6-oxo-5,6-dihydro-indolizine-7-carboxylic acid methyl ester; In toluene; at 100 ℃; for 4h; sealed vial;

With triethylamine; In toluene; at 25 - 100 ℃; for 64h; sealed vial;

With hydrogenchloride; In water; toluene;

Reference yield:

: 1193-62-0
methyl Pyrrole-2-carboxylate

: 1056901-39-3
{3-[5-(3-chloro-4-fluoro-benzyl)-8-hydroxy-5-methyl-6-oxo-5,6-dihydro-indolizin-7-yl]-1,1-dioxo-1,4-dihydro-1λ6-benzo[1,2,4]thiadiazin-7-yl}-carbamic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 8 steps

1.1: sodium hydride / N,N-dimethyl-formamide / 0.53 h

1.2: 0.75 h / 80 °C

2.1: potassium hexamethylsilazane / tetrahydrofuran; toluene / 0.67 h / -78 °C

2.2: 14.03 h / -78 - 25 °C

3.1: trifluoroacetic acid / dichloromethane / 4 h / 25 °C

4.1: oxalyl dichloride / N,N-dimethyl-formamide / dichloromethane / 0.5 h / 25 °C

5.1: sodium hydride / tetrahydrofuran / 0.33 h / 25 °C

5.2: 16 h / 25 °C

6.1: hydrogen / 5%-palladium/activated carbon / methanol; ethyl acetate / 4 h / 25 °C

7.1: sodium methylate / methanol / 2.5 h / 25 °C

8.1: toluene / 4 h / 100 °C / sealed vial

8.2: 64 h / 25 - 100 °C / sealed vial

With oxalyl dichloride; hydrogen; sodium methylate; potassium hexamethylsilazane; sodium hydride; trifluoroacetic acid; 5%-palladium/activated carbon; N,N-dimethyl-formamide; In tetrahydrofuran; methanol; dichloromethane; ethyl acetate; N,N-dimethyl-formamide; toluene;

Reference yield:

: 1056901-33-7
1-(1-tert-butoxycarbonyl-ethyl)-1H-pyrrole-2-carboxylic acid methyl ester

: 1056901-39-3
{3-[5-(3-chloro-4-fluoro-benzyl)-8-hydroxy-5-methyl-6-oxo-5,6-dihydro-indolizin-7-yl]-1,1-dioxo-1,4-dihydro-1λ6-benzo[1,2,4]thiadiazin-7-yl}-carbamic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 7 steps

1.1: potassium hexamethylsilazane / tetrahydrofuran; toluene / 0.67 h / -78 °C

1.2: 14.03 h / -78 - 25 °C

2.1: trifluoroacetic acid / dichloromethane / 4 h / 25 °C

3.1: oxalyl dichloride / N,N-dimethyl-formamide / dichloromethane / 0.5 h / 25 °C

4.1: sodium hydride / tetrahydrofuran / 0.33 h / 25 °C

4.2: 16 h / 25 °C

5.1: hydrogen / 5%-palladium/activated carbon / methanol; ethyl acetate / 4 h / 25 °C

6.1: sodium methylate / methanol / 2.5 h / 25 °C

7.1: toluene / 4 h / 100 °C / sealed vial

7.2: 64 h / 25 - 100 °C / sealed vial

With oxalyl dichloride; hydrogen; sodium methylate; potassium hexamethylsilazane; sodium hydride; trifluoroacetic acid; 5%-palladium/activated carbon; N,N-dimethyl-formamide; In tetrahydrofuran; methanol; dichloromethane; ethyl acetate; toluene;