Methyl 2-[2-(2,6,6-trimethylcyclohex-1-en-1-yl)ethyl]-4-oxo-4H-1-benzopyran-3-carboxylate

Base Information

Chemical Name:Methyl 2-[2-(2,6,6-trimethylcyclohex-1-en-1-yl)ethyl]-4-oxo-4H-1-benzopyran-3-carboxylate
CAS No.:163041-10-9
Molecular Formula:C₂₂H₂₆O₄
Molecular Weight:354.446
Hs Code.:

Synonyms:Methyl 2-[2-(2,6,6-trimethylcyclohex-1-en-1-yl)ethyl]-4-oxo-4H-1-benzopyran-3-carboxylate

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Chemical Property of Methyl 2-[2-(2,6,6-trimethylcyclohex-1-en-1-yl)ethyl]-4-oxo-4H-1-benzopyran-3-carboxylate

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Technology Process of Methyl 2-[2-(2,6,6-trimethylcyclohex-1-en-1-yl)ethyl]-4-oxo-4H-1-benzopyran-3-carboxylate

There total 6 articles about Methyl 2-[2-(2,6,6-trimethylcyclohex-1-en-1-yl)ethyl]-4-oxo-4H-1-benzopyran-3-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

: 59633-89-5
3-oxo-5-(2,6,6-trimethyl-cyclohex-1-enyl)-pentanoic acid methyl ester

: 393-52-2
2-Fluorobenzoyl chloride

: 163041-10-9
Methyl 2-[2-(2,6,6-trimethylcyclohex-1-en-1-yl)ethyl]-4-oxo-4H-1-benzopyran-3-carboxylate

Guidance literature:: 3-oxo-5-(2,6,6-trimethyl-cyclohex-1-enyl)-pentanoic acid methyl ester; With sodium hydride; In toluene; at 50 ℃; for 1h;

2-Fluorobenzoyl chloride; In toluene; at 110 ℃; for 72h; Further stages.;
DOI:10.1039/b005617k

Reference yield:

: 59633-88-4
2-(bromomethyl)-1,3,3-trimethylcyclohex-1-ene

: 163041-10-9
Methyl 2-[2-(2,6,6-trimethylcyclohex-1-en-1-yl)ethyl]-4-oxo-4H-1-benzopyran-3-carboxylate

Guidance literature:: Multi-step reaction with 2 steps

1.1: NaH; n-BuLi / tetrahydrofuran / 0.33 h / 0 °C

1.2: 60 percent / tetrahydrofuran / 0.5 h / 20 °C

2.1: NaH / toluene / 1 h / 50 °C

2.2: 89 percent / toluene / 72 h / 110 °C

With n-butyllithium; sodium hydride; In tetrahydrofuran; toluene;
DOI:10.1039/b005617k

Reference yield:

: 79-77-6,14901-07-6
(E)-β-ionone

: 163041-10-9
Methyl 2-[2-(2,6,6-trimethylcyclohex-1-en-1-yl)ethyl]-4-oxo-4H-1-benzopyran-3-carboxylate

Guidance literature:: Multi-step reaction with 5 steps

1.1: O₃; O₂ / methanol / 6 h / -30 °C

1.2: 65 percent / Zn; aq. HOAc / methanol / 1.5 h / -30 - 25 °C

2.1: 85 percent / NaBH₄ / ethanol; propan-2-ol / 1 h / 20 °C

3.1: 98 percent / PBr₃ / hexane; diethyl ether / 15 h / -30 - 20 °C

4.1: NaH; n-BuLi / tetrahydrofuran / 0.33 h / 0 °C

4.2: 60 percent / tetrahydrofuran / 0.5 h / 20 °C

5.1: NaH / toluene / 1 h / 50 °C

5.2: 89 percent / toluene / 72 h / 110 °C

With sodium tetrahydroborate; n-butyllithium; oxygen; phosphorus tribromide; sodium hydride; ozone; In tetrahydrofuran; methanol; diethyl ether; ethanol; hexane; isopropyl alcohol; toluene;
DOI:10.1039/b005617k