(2E)-3-(1-((E)-1-cyclobutyl-3-phenylallyl)-1H-1,2,3-triazol-4-yl)-N-hydroxyacrylamide

Base Information

Chemical Name:(2E)-3-(1-((E)-1-cyclobutyl-3-phenylallyl)-1H-1,2,3-triazol-4-yl)-N-hydroxyacrylamide
CAS No.:1314801-88-1
Molecular Formula:C₁₈H₂₀N₄O₂
Molecular Weight:324.382
Hs Code.:

Synonyms:(2E)-3-(1-((E)-1-cyclobutyl-3-phenylallyl)-1H-1,2,3-triazol-4-yl)-N-hydroxyacrylamide

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Chemical Property of (2E)-3-(1-((E)-1-cyclobutyl-3-phenylallyl)-1H-1,2,3-triazol-4-yl)-N-hydroxyacrylamide

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Technology Process of (2E)-3-(1-((E)-1-cyclobutyl-3-phenylallyl)-1H-1,2,3-triazol-4-yl)-N-hydroxyacrylamide

There total 7 articles about (2E)-3-(1-((E)-1-cyclobutyl-3-phenylallyl)-1H-1,2,3-triazol-4-yl)-N-hydroxyacrylamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 45.0%

: 1314802-27-1
(2E)-N-(4-methoxybenzyloxy)-3-(1-((E)-1-cyclobutyl-3-phenylallyl)-1H-1,2,3-triazol-4yl)acrylamide

: 1314801-88-1
(2E)-3-(1-((E)-1-cyclobutyl-3-phenylallyl)-1H-1,2,3-triazol-4-yl)-N-hydroxyacrylamide

Guidance literature:: With chlorotriisopropylsilane; trifluoroacetic acid; In dichloromethane; at 20 ℃;
DOI:10.1016/j.ejmech.2011.04.027

Reference yield:

: 14371-10-9
(E)-3-phenylpropenal

: 1314801-88-1
(2E)-3-(1-((E)-1-cyclobutyl-3-phenylallyl)-1H-1,2,3-triazol-4-yl)-N-hydroxyacrylamide

Guidance literature:: Multi-step reaction with 4 steps

1.1: 0 - 20 °C / Inert atmosphere

1.2: Saturated solution

2.1: diphenyl phosphoryl azide; 1,8-diazabicyclo[5.4.0]undec-7-ene / toluene / 0 - 20 °C

3.1: triethylphosphite copper(I) iodide complex; N-ethyl-N,N-diisopropylamine / tetrahydrofuran / 20 °C

4.1: chlorotriisopropylsilane; trifluoroacetic acid / dichloromethane / 20 °C

With triethylphosphite copper(I) iodide complex; chlorotriisopropylsilane; diphenyl phosphoryl azide; 1,8-diazabicyclo[5.4.0]undec-7-ene; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; In tetrahydrofuran; dichloromethane; toluene;
DOI:10.1016/j.ejmech.2011.04.027

Reference yield:

: 1092115-32-6
(E)-N-(4-methoxybenzyloxy)-5-(trimethylsilyl)pent-2-en-4-ynamide

: 1314801-88-1
(2E)-3-(1-((E)-1-cyclobutyl-3-phenylallyl)-1H-1,2,3-triazol-4-yl)-N-hydroxyacrylamide

Guidance literature:: Multi-step reaction with 3 steps

1: cesium fluoride

2: triethylphosphite copper(I) iodide complex; N-ethyl-N,N-diisopropylamine / tetrahydrofuran / 20 °C

3: chlorotriisopropylsilane; trifluoroacetic acid / dichloromethane / 20 °C

With triethylphosphite copper(I) iodide complex; chlorotriisopropylsilane; N-ethyl-N,N-diisopropylamine; cesium fluoride; trifluoroacetic acid; In tetrahydrofuran; dichloromethane;
DOI:10.1016/j.ejmech.2011.04.027