1-[2-chloro-2-(4-iodophenyl)ethyl]-N-phenyl-1H-pyrazolo[3,4-d]pyrimidin-4-amine

Base Information

• Chemical Name: 1-[2-chloro-2-(4-iodophenyl)ethyl]-N-phenyl-1H-pyrazolo[3,4-d]pyrimidin-4-amine
• CAS No.: 1443752-73-5
• Molecular Formula: C₁₉H₁₅ClIN₅
• Molecular Weight: 475.719

Synonyms:1-[2-chloro-2-(4-iodophenyl)ethyl]-N-phenyl-1H-pyrazolo[3,4-d]pyrimidin-4-amine

Chemical Property of 1-[2-chloro-2-(4-iodophenyl)ethyl]-N-phenyl-1H-pyrazolo[3,4-d]pyrimidin-4-amine

Chemical Property:

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Technology Process of 1-[2-chloro-2-(4-iodophenyl)ethyl]-N-phenyl-1H-pyrazolo[3,4-d]pyrimidin-4-amine

There total 5 articles about 1-[2-chloro-2-(4-iodophenyl)ethyl]-N-phenyl-1H-pyrazolo[3,4-d]pyrimidin-4-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.0%

4-chloro-1-[2-chloro-2-(4-iodophenyl)ethyl]-1H-pyrazolo[3,4-d]-pyrimidine (1443752-71-3) + aniline (62-53-3) → 1-[2-chloro-2-(4-iodophenyl)ethyl]-N-phenyl-1H-pyrazolo[3,4-d]pyrimidin-4-amine (1443752-73-5)

Guidance literature:

In ethanol; Reflux;

DOI:10.1021/jm400233w

Reference yield:

4-chloro-1H-pyrazolo[3,4-d]pyrimidine (5399-92-8) → 1-[2-chloro-2-(4-iodophenyl)ethyl]-N-phenyl-1H-pyrazolo[3,4-d]pyrimidin-4-amine (1443752-73-5)

Guidance literature:

Multi-step reaction with 4 steps

1: tetrabutyl ammonium fluoride / tetrahydrofuran / 24 h / 20 °C

2: sodium tetrahydroborate / tetrahydrofuran / 0 °C

3: trichlorophosphate; N,N-dimethyl-formamide / 5 h / Reflux

4: ethanol / Reflux

With sodium tetrahydroborate; tetrabutyl ammonium fluoride; N,N-dimethyl-formamide; trichlorophosphate; In tetrahydrofuran; ethanol;

DOI:10.1021/jm400233w

Reference yield:

2-(4-chloro-1H-pyrazolo[3,4-d]pyrimidin-1-yl)-1-(4-iodophenyl)-ethanone (1443752-67-7) → 1-[2-chloro-2-(4-iodophenyl)ethyl]-N-phenyl-1H-pyrazolo[3,4-d]pyrimidin-4-amine (1443752-73-5)

Guidance literature:

Multi-step reaction with 3 steps

1: sodium tetrahydroborate / tetrahydrofuran / 0 °C

2: trichlorophosphate; N,N-dimethyl-formamide / 5 h / Reflux

3: ethanol / Reflux

With sodium tetrahydroborate; N,N-dimethyl-formamide; trichlorophosphate; In tetrahydrofuran; ethanol;

DOI:10.1021/jm400233w

upstream raw materials:

4-chloro-1-[2-chloro-2-(4-iodophenyl)ethyl]-1H-pyrazolo[3,4-d]-pyrimidine

aniline

4-hydroxypyrazolo(3,4-d)pyrimidine

4-chloro-1H-pyrazolo[3,4-d]pyrimidine

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