dimethyl (S)-3-(benzyloxy)-1-(3-((tert-butoxycarbonyl)amino)-1,1-diphenylpropan-2-yl)-4-oxo-1,4-dihydropyridine-2,5-dicarboxylate

Base Information

Chemical Name:dimethyl (S)-3-(benzyloxy)-1-(3-((tert-butoxycarbonyl)amino)-1,1-diphenylpropan-2-yl)-4-oxo-1,4-dihydropyridine-2,5-dicarboxylate
CAS No.:1246617-04-8
Molecular Formula:C₃₆H₃₈N₂O₈
Molecular Weight:626.706
Hs Code.:

Synonyms:dimethyl (S)-3-(benzyloxy)-1-(3-((tert-butoxycarbonyl)amino)-1,1-diphenylpropan-2-yl)-4-oxo-1,4-dihydropyridine-2,5-dicarboxylate

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Chemical Property of dimethyl (S)-3-(benzyloxy)-1-(3-((tert-butoxycarbonyl)amino)-1,1-diphenylpropan-2-yl)-4-oxo-1,4-dihydropyridine-2,5-dicarboxylate

Chemical Property:

Purity/Quality:: 98% ^*data from raw suppliers

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Technology Process of dimethyl (S)-3-(benzyloxy)-1-(3-((tert-butoxycarbonyl)amino)-1,1-diphenylpropan-2-yl)-4-oxo-1,4-dihydropyridine-2,5-dicarboxylate

There total 10 articles about dimethyl (S)-3-(benzyloxy)-1-(3-((tert-butoxycarbonyl)amino)-1,1-diphenylpropan-2-yl)-4-oxo-1,4-dihydropyridine-2,5-dicarboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 79.0%

: 1160984-36-0
tert-butyl (S)-(2-amino-3,3-diphenylpropyl)carbamate

: 1246616-66-9
dimethyl 3-(benzyloxy)-4-oxo-4H-pyran-2,5-dicarboxylate

: 1246617-04-8
dimethyl (S)-3-(benzyloxy)-1-(3-((tert-butoxycarbonyl)amino)-1,1-diphenylpropan-2-yl)-4-oxo-1,4-dihydropyridine-2,5-dicarboxylate

Guidance literature:: In toluene; at 110 ℃; for 5h;
DOI:10.1021/acs.jmedchem.9b00861

Reference yield:

: 32807-28-6,935731-94-5
Methyl 4-chloroacetoacetate

: 1246617-04-8
dimethyl (S)-3-(benzyloxy)-1-(3-((tert-butoxycarbonyl)amino)-1,1-diphenylpropan-2-yl)-4-oxo-1,4-dihydropyridine-2,5-dicarboxylate

Guidance literature:: Multi-step reaction with 4 steps

1.1: sodium tert-pentoxide / tetrahydrofuran / 2 h / 20 - 40 °C / Inert atmosphere

1.2: 2 h / 0 - 20 °C / Cooling with ice

2.1: 1,4-dioxane / 6 h / 20 °C

3.1: sodium t-butanolate / 1,3-dimethyl-2-imidazolidinone / 7 h / 20 - 30 °C / Inert atmosphere

3.2: 15 h / 20 °C

4.1: toluene / 5 h / 110 °C

With sodium tert-pentoxide; sodium t-butanolate; In tetrahydrofuran; 1,4-dioxane; 1,3-dimethyl-2-imidazolidinone; toluene;

Reference yield:

: 100-51-6,185532-71-2
benzyl alcohol

: 1246617-04-8
dimethyl (S)-3-(benzyloxy)-1-(3-((tert-butoxycarbonyl)amino)-1,1-diphenylpropan-2-yl)-4-oxo-1,4-dihydropyridine-2,5-dicarboxylate

Guidance literature:: Multi-step reaction with 4 steps

1.1: sodium tert-pentoxide / tetrahydrofuran / 2 h / 20 - 40 °C / Inert atmosphere

1.2: 2 h / 0 - 20 °C / Cooling with ice

2.1: 1,4-dioxane / 6 h / 20 °C

3.1: sodium t-butanolate / 1,3-dimethyl-2-imidazolidinone / 7 h / 20 - 30 °C / Inert atmosphere

3.2: 15 h / 20 °C

4.1: toluene / 5 h / 110 °C

With sodium tert-pentoxide; sodium t-butanolate; In tetrahydrofuran; 1,4-dioxane; 1,3-dimethyl-2-imidazolidinone; toluene;