(1'R,2R,3R,4R,5R)-N-butyloxycarbonyl-3,4-bis(benzyloxy)-5-<(benzyloxy)methyl>-2-<2-azido-1-hydroxyethyl>pyrrolidine

Base Information

Chemical Name:(1'R,2R,3R,4R,5R)-N-butyloxycarbonyl-3,4-bis(benzyloxy)-5-<(benzyloxy)methyl>-2-<2-azido-1-hydroxyethyl>pyrrolidine
CAS No.:231618-98-7
Molecular Formula:C₃₃H₄₀N₄O₆
Molecular Weight:588.704
Hs Code.:

Synonyms:(1'R,2R,3R,4R,5R)-N-butyloxycarbonyl-3,4-bis(benzyloxy)-5-<(benzyloxy)methyl>-2-<2-azido-1-hydroxyethyl>pyrrolidine

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Chemical Property of (1'R,2R,3R,4R,5R)-N-butyloxycarbonyl-3,4-bis(benzyloxy)-5-<(benzyloxy)methyl>-2-<2-azido-1-hydroxyethyl>pyrrolidine

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Technology Process of (1'R,2R,3R,4R,5R)-N-butyloxycarbonyl-3,4-bis(benzyloxy)-5-<(benzyloxy)methyl>-2-<2-azido-1-hydroxyethyl>pyrrolidine

There total 4 articles about (1'R,2R,3R,4R,5R)-N-butyloxycarbonyl-3,4-bis(benzyloxy)-5-<(benzyloxy)methyl>-2-<2-azido-1-hydroxyethyl>pyrrolidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 69.0%

: 231618-97-6
(2R,3R,4R,5R)-3,4-Bis-benzyloxy-2-benzyloxymethyl-5-[(S)-1-hydroxy-2-(toluene-4-sulfonyloxy)-ethyl]-pyrrolidine-1-carboxylic acid tert-butyl ester

: 231618-98-7
(1'R,2R,3R,4R,5R)-N-butyloxycarbonyl-3,4-bis(benzyloxy)-5-<(benzyloxy)methyl>-2-<2-azido-1-hydroxyethyl>pyrrolidine

Guidance literature:: With sodium azide; In N,N-dimethyl-formamide; at 70 ℃; for 4h;
DOI:10.1021/jo9902446

Reference yield:

: 24424-99-5
di-tert-butyl dicarbonate

: 231618-98-7
(1'R,2R,3R,4R,5R)-N-butyloxycarbonyl-3,4-bis(benzyloxy)-5-<(benzyloxy)methyl>-2-<2-azido-1-hydroxyethyl>pyrrolidine

Guidance literature:: Multi-step reaction with 3 steps

1: 91 percent / Et₃N / CH₂Cl₂ / 20 h / Ambient temperature

2: 85 percent / pyridine / 37 h / Ambient temperature

3: 69 percent / NaN₃ / dimethylformamide / 4 h / 70 °C

With sodium azide; triethylamine; In pyridine; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/jo9902446

Reference yield:

: 231619-09-3
(2R,3S,4S,5R,6R)-6-azido-2,3-epoxy-4,5,7-tris(benzyloxy)-2(E)-hepten-1-ol

: 231618-98-7
(1'R,2R,3R,4R,5R)-N-butyloxycarbonyl-3,4-bis(benzyloxy)-5-<(benzyloxy)methyl>-2-<2-azido-1-hydroxyethyl>pyrrolidine

Guidance literature:: Multi-step reaction with 4 steps

1: 91 percent / PPh₃ / tetrahydrofuran; H₂O / 48 h / Ambient temperature

2: 91 percent / Et₃N / CH₂Cl₂ / 20 h / Ambient temperature

3: 85 percent / pyridine / 37 h / Ambient temperature

4: 69 percent / NaN₃ / dimethylformamide / 4 h / 70 °C

With sodium azide; triethylamine; triphenylphosphine; In tetrahydrofuran; pyridine; dichloromethane; water; N,N-dimethyl-formamide;
DOI:10.1021/jo9902446