1-[3-(Trifluoromethyl)phenyl]cyclopropan-1-ol

Base Information

Chemical Name:1-[3-(Trifluoromethyl)phenyl]cyclopropan-1-ol
CAS No.:43187-68-4
Molecular Formula:C₁₀H₉F₃O
Molecular Weight:202.176
Hs Code.:
European Community (EC) Number:868-475-4

Synonyms:1-[3-(trifluoromethyl)phenyl]cyclopropan-1-ol;43187-68-4;1-(3-(TRIFLUOROMETHYL)PHENYL)CYCLOPROPAN-1-OL;AKOS011962993;AT26823;1-[3-(Trifluoromethyl)phenyl]cyclopropanol;CS-0238309;EN300-1929939

Suppliers and Price of 1-[3-(Trifluoromethyl)phenyl]cyclopropan-1-ol

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Total 1 raw suppliers

Chemical Property of 1-[3-(Trifluoromethyl)phenyl]cyclopropan-1-ol

Chemical Property:

XLogP3:2.3
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:1
Exact Mass:202.06054939
Heavy Atom Count:14
Complexity:220

Purity/Quality:: 99% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:C1CC1(C2=CC(=CC=C2)C(F)(F)F)O

Technology Process of 1-[3-(Trifluoromethyl)phenyl]cyclopropan-1-ol

There total 5 articles about 1-[3-(Trifluoromethyl)phenyl]cyclopropan-1-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

: 1006613-82-6
1-(benzenesulfonyl)cyclopropanol

: 401-78-5
3-bromo-1-trifluoromethylbenzene

: 43187-68-4
1-(3-(trifluoromethyl)phenyl)cyclopropan-1-ol

Guidance literature:: 3-bromo-1-trifluoromethylbenzene; With magnesium; In tetrahydrofuran; Inert atmosphere; Reflux;

1-(benzenesulfonyl)cyclopropanol; In tetrahydrofuran; at 0 - 20 ℃; for 5h;
DOI:10.1021/acs.orglett.0c02303

Reference yield:

: 76783-59-0
ethyl 3-(trifluoromethyl)benzoate

: 925-90-6
ethylmagnesium bromide

: 43187-68-4
1-(3-(trifluoromethyl)phenyl)cyclopropan-1-ol

Guidance literature:: With titanium(IV) isopropylate; In tetrahydrofuran; at 0 - 20 ℃; for 12.5h; Inert atmosphere;
DOI:10.1002/anie.202110709

Reference yield:

: 64362-16-9
trimethyl({1-[3-(trifluoromethyl)phenyl]ethenyl}oxy)silane

: 43187-68-4
1-(3-(trifluoromethyl)phenyl)cyclopropan-1-ol

Guidance literature:: Multi-step reaction with 2 steps

1: diethylzinc / dichloromethane; tetrahydrofuran / 16 h / 0 - 20 °C / Inert atmosphere

2: potassium carbonate; methanol / 0.5 h / 20 °C / Inert atmosphere

With methanol; diethylzinc; potassium carbonate; In tetrahydrofuran; dichloromethane;
DOI:10.1039/c5ob00632e