iso-propyl 4-((4-((5-methyl-1H-pyrazol-3-yl)amino)-6-(4-methylpiperazin-1-yl)pyrimidin-2-yl)amino)benzoate

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Chemical Name:iso-propyl 4-((4-((5-methyl-1H-pyrazol-3-yl)amino)-6-(4-methylpiperazin-1-yl)pyrimidin-2-yl)amino)benzoate
CAS No.:1432515-55-3
Molecular Formula:C₂₃H₃₀N₈O₂
Molecular Weight:450.544
Hs Code.:

Synonyms:iso-propyl 4-((4-((5-methyl-1H-pyrazol-3-yl)amino)-6-(4-methylpiperazin-1-yl)pyrimidin-2-yl)amino)benzoate

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Chemical Property of iso-propyl 4-((4-((5-methyl-1H-pyrazol-3-yl)amino)-6-(4-methylpiperazin-1-yl)pyrimidin-2-yl)amino)benzoate

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Technology Process of iso-propyl 4-((4-((5-methyl-1H-pyrazol-3-yl)amino)-6-(4-methylpiperazin-1-yl)pyrimidin-2-yl)amino)benzoate

There total 2 articles about iso-propyl 4-((4-((5-methyl-1H-pyrazol-3-yl)amino)-6-(4-methylpiperazin-1-yl)pyrimidin-2-yl)amino)benzoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 49.0%

: 109-01-3
1-methyl-piperazine

: 1605398-06-8
iso-propyl 4-((4-chloro-6-((5-methyl-1H-pyrazol-3-yl)amino)pyrimidin-2-yl)amino)benzoate

: 1432515-55-3
iso-propyl 4-((4-((5-methyl-1H-pyrazol-3-yl)amino)-6-(4-methylpiperazin-1-yl)pyrimidin-2-yl)amino)benzoate

Guidance literature:: In 1,4-dioxane; at 140 ℃; for 0.5h; Microwave irradiation;
DOI:10.1016/j.ejmech.2014.03.027

Reference yield:

: 851435-01-3
2,6-di-chloro-N-(5-methyl-1H-pyrazol-3-yl)pyrimidin-4-amine

: 1432515-55-3
iso-propyl 4-((4-((5-methyl-1H-pyrazol-3-yl)amino)-6-(4-methylpiperazin-1-yl)pyrimidin-2-yl)amino)benzoate

Guidance literature:: Multi-step reaction with 2 steps

1: toluene-4-sulfonic acid / butan-1-ol / 12 h / 130 °C

2: 1,4-dioxane / 0.5 h / 140 °C / Microwave irradiation

With toluene-4-sulfonic acid; In 1,4-dioxane; butan-1-ol;
DOI:10.1016/j.ejmech.2014.03.027