Technology Process of Boc-PheΨGly-Sta-Leu-NHCH2Ph
There total 7 articles about Boc-PheΨGly-Sta-Leu-NHCH2Ph which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
Multi-step reaction with 7 steps
1: 1-methylpiperidine / ethyl acetate / 0.17 h / -20 °C
2: ethyl acetate; diethyl ether / 2 °C / overnight
3: HBr gas / diethyl ether / -20 °C
4: 1.) NaH / 1.) THF, 1 h, 2.) a) 0 deg C, 0.5 h, b) room temp., 1 h
5: H2 / 20percent Pd/C / methanol / 3 h
6: toluene / 2 h / Heating
7: HOBT/DCC, Et3N / dimethylformamide / Ambient temperature
With
N-methylcyclohexylamine; hydrogen bromide; hydrogen; sodium hydride; benzotriazol-1-ol; triethylamine; dicyclohexyl-carbodiimide;
palladium on activated charcoal;
In
methanol; diethyl ether; ethyl acetate; N,N-dimethyl-formamide; toluene;
DOI:10.1021/jm00164a058
- Guidance literature:
-
Multi-step reaction with 4 steps
1: 1.) NaH / 1.) THF, 1 h, 2.) a) 0 deg C, 0.5 h, b) room temp., 1 h
2: H2 / 20percent Pd/C / methanol / 3 h
3: toluene / 2 h / Heating
4: HOBT/DCC, Et3N / dimethylformamide / Ambient temperature
With
hydrogen; sodium hydride; benzotriazol-1-ol; triethylamine; dicyclohexyl-carbodiimide;
palladium on activated charcoal;
In
methanol; N,N-dimethyl-formamide; toluene;
DOI:10.1021/jm00164a058
- Guidance literature:
-
Multi-step reaction with 5 steps
1: HBr gas / diethyl ether / -20 °C
2: 1.) NaH / 1.) THF, 1 h, 2.) a) 0 deg C, 0.5 h, b) room temp., 1 h
3: H2 / 20percent Pd/C / methanol / 3 h
4: toluene / 2 h / Heating
5: HOBT/DCC, Et3N / dimethylformamide / Ambient temperature
With
hydrogen bromide; hydrogen; sodium hydride; benzotriazol-1-ol; triethylamine; dicyclohexyl-carbodiimide;
palladium on activated charcoal;
In
methanol; diethyl ether; N,N-dimethyl-formamide; toluene;
DOI:10.1021/jm00164a058
