Acetic acid (R)-1-[4-benzyloxy-2-(2,2-dimethoxy-ethyl)-phenyl]-2-(3-benzyloxy-phenyl)-ethyl ester

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Chemical Name:Acetic acid (R)-1-[4-benzyloxy-2-(2,2-dimethoxy-ethyl)-phenyl]-2-(3-benzyloxy-phenyl)-ethyl ester
CAS No.:233597-99-4
Molecular Formula:C₃₄H₃₆O₆
Molecular Weight:540.656
Hs Code.:

Synonyms:Acetic acid (R)-1-[4-benzyloxy-2-(2,2-dimethoxy-ethyl)-phenyl]-2-(3-benzyloxy-phenyl)-ethyl ester

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Chemical Property of Acetic acid (R)-1-[4-benzyloxy-2-(2,2-dimethoxy-ethyl)-phenyl]-2-(3-benzyloxy-phenyl)-ethyl ester

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Technology Process of Acetic acid (R)-1-[4-benzyloxy-2-(2,2-dimethoxy-ethyl)-phenyl]-2-(3-benzyloxy-phenyl)-ethyl ester

There total 5 articles about Acetic acid (R)-1-[4-benzyloxy-2-(2,2-dimethoxy-ethyl)-phenyl]-2-(3-benzyloxy-phenyl)-ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 43.6%

: 108-24-7
acetic anhydride

: 233597-93-8
(+/-)-1-<2-(2,2-dimethoxyethyl)-4-(benzyloxy)phenyl>-2-<(3-benzyloxy)phenyl>ethan-1-ol

: (S)-(+)-1-<2-(2,2-dimethoxyethyl)-4-(benzyloxy)phenyl>-2-<(3-benzyloxy)phenyl>ethan-1-ol

: 233597-99-4
Acetic acid (R)-1-[4-benzyloxy-2-(2,2-dimethoxy-ethyl)-phenyl]-2-(3-benzyloxy-phenyl)-ethyl ester

Guidance literature:: With chiral ferrocene derivative; TEA; In tert-Amyl alcohol; at 0 ℃; for 50h;
DOI:10.1021/jo990031g

Reference yield:

: 2973-80-0
2-bromo-5-hydroxybenzaldehyde

: 233597-99-4
Acetic acid (R)-1-[4-benzyloxy-2-(2,2-dimethoxy-ethyl)-phenyl]-2-(3-benzyloxy-phenyl)-ethyl ester

Guidance literature:: Multi-step reaction with 5 steps

1: 74 percent / NaH / tetrahydrofuran; dimethylformamide / Ambient temperature

2: 1.) LDA / 1.) THF, room temperature, 1-2 h, 2.) THF, room temperature, 8 h

3: conc. H₂SO₄ / methanol / 4 h / Heating

4: 1.) n-BuLi / 1.) THF, -78 deg C, 1 h, 2.) THF, -78 deg C, 1 h; room temperature, 1 h

5: 43.6 percent / TEA, chiral ferrocene derivative / 2-methyl-butan-2-ol / 50 h / 0 °C

With n-butyllithium; chiral ferrocene derivative; TEA; sulfuric acid; sodium hydride; lithium diisopropyl amide; In tetrahydrofuran; methanol; tert-Amyl alcohol; N,N-dimethyl-formamide;
DOI:10.1021/jo990031g

Reference yield:

: 85604-06-4
5-(benzyloxy)-2-bromobenzaldehyde

: 233597-99-4
Acetic acid (R)-1-[4-benzyloxy-2-(2,2-dimethoxy-ethyl)-phenyl]-2-(3-benzyloxy-phenyl)-ethyl ester

Guidance literature:: Multi-step reaction with 4 steps

1: 1.) LDA / 1.) THF, room temperature, 1-2 h, 2.) THF, room temperature, 8 h

2: conc. H₂SO₄ / methanol / 4 h / Heating

3: 1.) n-BuLi / 1.) THF, -78 deg C, 1 h, 2.) THF, -78 deg C, 1 h; room temperature, 1 h

4: 43.6 percent / TEA, chiral ferrocene derivative / 2-methyl-butan-2-ol / 50 h / 0 °C

With n-butyllithium; chiral ferrocene derivative; TEA; sulfuric acid; lithium diisopropyl amide; In methanol; tert-Amyl alcohol;
DOI:10.1021/jo990031g