Pioglitazone hydrochloride specified impurity B [EP]

Base Information Edit

Chemical Name:Pioglitazone hydrochloride specified impurity B [EP]
CAS No.:144809-28-9
Molecular Formula:C19H18N2O3S
Molecular Weight:354.43
Hs Code.:
DSSTox Substance ID:DTXSID20929380
Mol file:144809-28-9.mol

Synonyms:UNII-6SE873CO82;Pioglitazone hydrochloride specified impurity B [EP];Pioglitazone hydrochloride impurity, didehydropioglitazone- [USP];DTXSID20929380;YNTUJOCADSTMCL-UHFFFAOYSA-N;BCP11936;AKOS030241531;FT-0645029;FT-0645357;FT-0652001;5-[4-[2-(5-ethyl-2-pyridyl) ethoxy]benzylidene]-2,4-thiazolidinedione;5-[4-[2-(5-ethyl-2-pyridyl)ethoxy]benzilidene]-2,4-thiazolidinedione;5-{4-[2-(5-ethyl-2-pyridyl)ethoxy]benzylidene}-2,4-thiazolidinedione;5-{4-[2-(5-ethyl-2-pyridyl)ethoxy]benzylidene}-2,4thiazolidinedione;5-({4-[2-(5-Ethylpyridin-2-yl)ethoxy]phenyl}methylidene)-4-hydroxy-1,3-thiazol-2(5H)-one

Suppliers and Price of Pioglitazone hydrochloride specified impurity B [EP]

Supply Marketing:Edit

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
5-[[4-[2-(5-Ethyl-2-pyridinyl)ethoxy]phenyl]-methylene]-2,4-thiazolidinedione(PioglitazoneImpurity)
100mg
$ 505.00

Crysdot
5-(4-(2-(5-Ethylpyridin-2-yl)ethoxy)benzylidene)thiazolidine-2,4-dione 95+%
1g
$ 405.00

Crysdot
5-(4-(2-(5-Ethylpyridin-2-yl)ethoxy)benzylidene)thiazolidine-2,4-dione 95+%
5g
$ 1217.00

Chemenu
5-(4-(2-(5-Ethylpyridin-2-yl)ethoxy)benzylidene)thiazolidine-2,4-dione 95%
5g
$ 1147.00

Chemenu
5-(4-(2-(5-Ethylpyridin-2-yl)ethoxy)benzylidene)thiazolidine-2,4-dione 95%
1g
$ 383.00

Biosynth Carbosynth
5-[[4-[2-(5-Ethyl-2-pyridinyl)ethoxy]phenyl]-methylene]-2,4-thiazolidinedione
50 mg
$ 396.50

Biosynth Carbosynth
5-[[4-[2-(5-Ethyl-2-pyridinyl)ethoxy]phenyl]-methylene]-2,4-thiazolidinedione
25 mg
$ 218.50

Biosynth Carbosynth
5-[[4-[2-(5-Ethyl-2-pyridinyl)ethoxy]phenyl]-methylene]-2,4-thiazolidinedione
10 mg
$ 120.10

Biosynth Carbosynth
5-[[4-[2-(5-Ethyl-2-pyridinyl)ethoxy]phenyl]-methylene]-2,4-thiazolidinedione
100 mg
$ 721.00

Biosynth Carbosynth
5-[[4-[2-(5-Ethyl-2-pyridinyl)ethoxy]phenyl]-methylene]-2,4-thiazolidinedione
250 mg
$ 1310.00

Total 91 raw suppliers

Chemical Property of Pioglitazone hydrochloride specified impurity B [EP] Edit

Chemical Property:

Appearance/Colour:white solid
Melting Point:156-159°C
Refractive Index:1.653
PKA:7.26±0.20(Predicted)
PSA：93.59000
Density:1.301 g/cm³
LogP:3.91820
Storage Temp.:-20°C Freezer
Solubility.:Acetonitrile (Slightly), Chloroform (Slightly), DMSO (Slightly)
XLogP3:3.9
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:5
Rotatable Bond Count:6
Exact Mass:354.10381361
Heavy Atom Count:25
Complexity:515

Purity/Quality:

99% ^*data from raw suppliers

5-[[4-[2-(5-Ethyl-2-pyridinyl)ethoxy]phenyl]-methylene]-2,4-thiazolidinedione(PioglitazoneImpurity) ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CCC1=CN=C(C=C1)CCOC2=CC=C(C=C2)C=C3C(=O)NC(=O)S3
Uses A novel intermediate of Pioglitazone (P471000). 5-[[4-[2-(5-Ethyl-2-pyridinyl)ethoxy]phenyl]-methylene]-2,4-thiazolidinedione (Pioglitazone EP Impurity B) is a novel intermediate of Pioglitazone (P471000).

Technology Process of Pioglitazone hydrochloride specified impurity B [EP]

There total 16 articles about Pioglitazone hydrochloride specified impurity B [EP] which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.5%