(3'-((difluoromethyl)oxy)-2-(2,2-dimethylcyclopentyl)-1,1'-biphenyl-4-yl)methanol

Base Information

Chemical Name:(3'-((difluoromethyl)oxy)-2-(2,2-dimethylcyclopentyl)-1,1'-biphenyl-4-yl)methanol
CAS No.:1142234-76-1
Molecular Formula:C₂₁H₂₄F₂O₂
Molecular Weight:346.417
Hs Code.:

Synonyms:(3'-((difluoromethyl)oxy)-2-(2,2-dimethylcyclopentyl)-1,1'-biphenyl-4-yl)methanol

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Chemical Property of (3'-((difluoromethyl)oxy)-2-(2,2-dimethylcyclopentyl)-1,1'-biphenyl-4-yl)methanol

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Technology Process of (3'-((difluoromethyl)oxy)-2-(2,2-dimethylcyclopentyl)-1,1'-biphenyl-4-yl)methanol

There total 14 articles about (3'-((difluoromethyl)oxy)-2-(2,2-dimethylcyclopentyl)-1,1'-biphenyl-4-yl)methanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1142224-93-8
(3'-((difluoromethyl)oxy)-2-(2,2-dimethylcyclopentyl)-1,1'-biphenyl-4-yl)methanol

: 1142234-76-1
(3'-((difluoromethyl)oxy)-2-(2,2-dimethylcyclopentyl)-1,1'-biphenyl-4-yl)methanol

: 1142234-74-9
(3'-((difluoromethyl)oxy)-2-(2,2-dimethylcyclopentyl)-1,1'-biphenyl-4-yl)methanol

Guidance literature:: With CHIRALCEL OD column; In hexane; isopropyl alcohol;

Reference yield:

: 176240-84-9
methyl 4-(benzyloxy)-3-bromobenzoate

: 1142234-76-1
(3'-((difluoromethyl)oxy)-2-(2,2-dimethylcyclopentyl)-1,1'-biphenyl-4-yl)methanol

: 1142234-74-9
(3'-((difluoromethyl)oxy)-2-(2,2-dimethylcyclopentyl)-1,1'-biphenyl-4-yl)methanol

Guidance literature:: Multi-step reaction with 6 steps

1.1: potassium phosphate / 2-dicyclohexylphosphino-2′,6′-dimethoxybiphenyl; palladium diacetate / water; N,N-dimethyl-formamide / 21 h / 75 °C / Inert atmosphere

2.1: hydrogen / palladium 10% on activated carbon / methanol / 27.5 h / 20 °C

3.1: dmap; triethylamine / dichloromethane / 0.33 h

3.2: 20 °C

4.1: potassium phosphate / 2-dicyclohexylphosphino-2′,6′-dimethoxybiphenyl; palladium diacetate / N,N-dimethyl-formamide / 16 h / 75 °C / Inert atmosphere

5.1: lithium aluminium tetrahydride / tetrahydrofuran / 0 °C

6.1: Chiracel-OD / hexane; isopropyl alcohol / Resolution of racemate

With dmap; potassium phosphate; lithium aluminium tetrahydride; hydrogen; triethylamine; 2-dicyclohexylphosphino-2′,6′-dimethoxybiphenyl; palladium 10% on activated carbon; palladium diacetate; In tetrahydrofuran; methanol; hexane; dichloromethane; water; N,N-dimethyl-formamide; isopropyl alcohol;

Reference yield:

: 1011531-89-7
2-(5,5-dimethylcyclopent-1-en-1-yl)-4,4,5,5-tetramethyl-1 ,3 ,2-dioxaborolane

: 1142234-76-1
(3'-((difluoromethyl)oxy)-2-(2,2-dimethylcyclopentyl)-1,1'-biphenyl-4-yl)methanol

: 1142234-74-9
(3'-((difluoromethyl)oxy)-2-(2,2-dimethylcyclopentyl)-1,1'-biphenyl-4-yl)methanol

Guidance literature:: Multi-step reaction with 6 steps

1.1: potassium phosphate / 2-dicyclohexylphosphino-2′,6′-dimethoxybiphenyl; palladium diacetate / water; N,N-dimethyl-formamide / 21 h / 75 °C / Inert atmosphere

2.1: hydrogen / palladium 10% on activated carbon / methanol / 27.5 h / 20 °C

3.1: dmap; triethylamine / dichloromethane / 0.33 h

3.2: 20 °C

4.1: potassium phosphate / 2-dicyclohexylphosphino-2′,6′-dimethoxybiphenyl; palladium diacetate / N,N-dimethyl-formamide / 16 h / 75 °C / Inert atmosphere

5.1: lithium aluminium tetrahydride / tetrahydrofuran / 0 °C

6.1: Chiracel-OD / hexane; isopropyl alcohol / Resolution of racemate

With dmap; potassium phosphate; lithium aluminium tetrahydride; hydrogen; triethylamine; 2-dicyclohexylphosphino-2′,6′-dimethoxybiphenyl; palladium 10% on activated carbon; palladium diacetate; In tetrahydrofuran; methanol; hexane; dichloromethane; water; N,N-dimethyl-formamide; isopropyl alcohol;