Diethyl-(2-{4-[3-(4-methyl-piperazin-1-yl)-propoxy]-2-nitro-phenylethynyl}-benzyl)-amine

Base Information

Chemical Name:Diethyl-(2-{4-[3-(4-methyl-piperazin-1-yl)-propoxy]-2-nitro-phenylethynyl}-benzyl)-amine
CAS No.:99562-27-3
Molecular Formula:C₂₇H₃₆N₄O₃
Molecular Weight:464.608
Hs Code.:

Synonyms:Diethyl-(2-{4-[3-(4-methyl-piperazin-1-yl)-propoxy]-2-nitro-phenylethynyl}-benzyl)-amine

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Chemical Property of Diethyl-(2-{4-[3-(4-methyl-piperazin-1-yl)-propoxy]-2-nitro-phenylethynyl}-benzyl)-amine

Chemical Property:

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Technology Process of Diethyl-(2-{4-[3-(4-methyl-piperazin-1-yl)-propoxy]-2-nitro-phenylethynyl}-benzyl)-amine

There total 10 articles about Diethyl-(2-{4-[3-(4-methyl-piperazin-1-yl)-propoxy]-2-nitro-phenylethynyl}-benzyl)-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

: 99558-04-0
NN-diethyl-o-ethynylbenzylamine

: 99558-02-8
4-<3-(4-methylpiperazin-1-yl)propoxy>-2-nitroiodobenzene

: 99562-27-3
Diethyl-(2-{4-[3-(4-methyl-piperazin-1-yl)-propoxy]-2-nitro-phenylethynyl}-benzyl)-amine

Guidance literature:: bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; In triethylamine; below 40 deg C;

Reference yield:

: 109-01-3
1-methyl-piperazine

: 99562-27-3
Diethyl-(2-{4-[3-(4-methyl-piperazin-1-yl)-propoxy]-2-nitro-phenylethynyl}-benzyl)-amine

Guidance literature:: Multi-step reaction with 6 steps

1: 67 percent / tetrahydrofuran / 24 h / Heating

2: 95 percent / hydrogen / 10percent palladium-charcoal / methanol / 2 h

3: 89 percent / benzene / 3 h / Heating

4: 80 percent / 25percent nitric acid / 2 h / Ambient temperature

5: 85 percent / Sandmeyer reaction

6: 85 percent / copper(I) iodide, bis(triphenylphosphine)palladium(II) dichloride / triethylamine / below 40 deg C

With hydrogen; nitric acid; bis-triphenylphosphine-palladium(II) chloride; palladium on activated charcoal; copper(l) iodide; In tetrahydrofuran; methanol; triethylamine; benzene;

Reference yield:

: 615-37-2
ortho-methylphenyl iodide

: 99562-27-3
Diethyl-(2-{4-[3-(4-methyl-piperazin-1-yl)-propoxy]-2-nitro-phenylethynyl}-benzyl)-amine

Guidance literature:: Multi-step reaction with 4 steps

1: 60 percent

2: 95 percent / tetrahydrofuran / Heating

3: 70 percent / anhydrous zinc chloride, tetrakis-(triphenylphosphine)palladium / copper(I) iodide / King's method

4: 85 percent / copper(I) iodide, bis(triphenylphosphine)palladium(II) dichloride / triethylamine / below 40 deg C

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; zinc(II) chloride; bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; In tetrahydrofuran; triethylamine;