1α-Fluoro-25-hydroxycholecalciferol

Base Information

Chemical Name:1α-Fluoro-25-hydroxycholecalciferol
CAS No.:95586-94-0
Molecular Formula:C₂₇H₄₃FO₂
Molecular Weight:418.636
Hs Code.:

Synonyms:1α-Fluoro-25-hydroxycholecalciferol

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Chemical Property of 1α-Fluoro-25-hydroxycholecalciferol

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Technology Process of 1α-Fluoro-25-hydroxycholecalciferol

There total 30 articles about 1α-Fluoro-25-hydroxycholecalciferol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

: 123836-64-6
<<(1α,3β,5Z,7E)-3-<<(1,1-Dimethylethyl)dimethylsilyl>oxy>-1-fluoro-9,10-secocholesta-5,7,10(19)-trien-25-yl>oxy>-trimethylsilane

: 95586-94-0
1α-Fluoro-25-hydroxycholecalciferol

Guidance literature:: With tetrabutyl ammonium fluoride; In tetrahydrofuran; at 20 ℃; for 15h;
DOI:10.1021/jo00288a040

Reference yield: 32.0%

: 95511-62-9
1α-fluoro-25-hydroxyvitamin D3 3-acetate

: 74041-09-1,74041-11-5,95586-94-0
1α-fluoro-25-hydroxyvitamin D3

Guidance literature:: With potassium hydroxide; In tetrahydrofuran; methanol; Ambient temperature;
DOI:10.1248/cpb.32.3525

Reference yield:

: 123836-62-4
<1R-(1β,3Z,5α)>-<<3-(2-Chloroethylidene)-5-fluoro-4-methylenecyclohexyl>oxy>(1,1-dimethylethyl)dimethylsilane

: 95586-94-0
1α-Fluoro-25-hydroxycholecalciferol

Guidance literature:: Multi-step reaction with 3 steps

1: 1.)0.338 M lithium diphenylphosphide, 2.)5percent H₂O₂ / 1.)THF, -75 deg C, 2.)CH₂Cl₂, R_.T_., 45 min.

2: 1.)n-BuLi / 1.)THF, -75 deg C, 6 min., 2.)THF, -75 deg C, 5 h

3: 90 percent / 1M tetrabutylammonium fluoride / tetrahydrofuran / 15 h / 20 °C

With n-butyllithium; tetrabutyl ammonium fluoride; dihydrogen peroxide; lithium diphenylphosphide; In tetrahydrofuran;
DOI:10.1021/jo00288a040