2-Fluoro-6-methylaniline

Base Information

• Chemical Name: 2-Fluoro-6-methylaniline
• CAS No.: 443-89-0
• Molecular Formula: C7H8FN
• Molecular Weight: 125.146
• Hs Code.: 29214300
• Mol file: 443-89-0.mol

Synonyms:o-Toluidine,6-fluoro- (7CI,8CI);2-Amino-3-Fluorotoluene;

Chemical Property of 2-Fluoro-6-methylaniline

Chemical Property:

• Vapor Pressure: 0.644mmHg at 25°C
• Melting Point: 0°C
• Refractive Index: n20/D 1.536
• Boiling Point: 187 °C at 760 mmHg
• PKA: 3.06±0.10(Predicted)
• Flash Point: 80.1 °C
• PSA: 26.02000
• Density: 1.115 g/cm³
• LogP: 2.29750
• Storage Temp.: 2-8°C

Purity/Quality:

99% ^*data from raw suppliers

2-Fluoro-6-methylaniline ^*data from reagent suppliers

Safty Information:

• Pictogram(s): T, Xn
• Hazard Codes: T,Xn
• Statements: 20/21/22-36/37/38-41-37/38-22
• Safety Statements: 26-36/37/39-39-60-23

MSDS Files:

SDS file from LookChem

Useful:

• Uses: 2-Fluoro-6-methylaniline is used in preparation of arylmethylene heterocyclic compounds as Kv1.3 potassium shaker channel blockers.

Technology Process of 2-Fluoro-6-methylaniline

There total 2 articles about 2-Fluoro-6-methylaniline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

1-fluoro-3-methyl-2-nitro-benzene (3013-27-2) → 2-fluoro-6-methylaniline (443-89-0)

Guidance literature:

With ethanol; nickel; Hydrogenation;

Reference yield:

→ 2-fluoro-6-methylaniline (443-89-0)

Guidance literature:

Reference yield: 92.8%

2-fluoro-6-methylaniline (443-89-0) → 4-bromo-2-fluoro-6-methylbenzeneamine (429683-46-5)

Guidance literature:

With N-Bromosuccinimide; In N,N-dimethyl-formamide; at 20 ℃; for 0.5h; Cooling with ice;

upstream raw materials:

1-fluoro-3-methyl-2-nitro-benzene

Downstream raw materials:

2-chloro-N-(2-fluoro-6-methylphenyl)acetamide

pyridine-2-carboxylic acid (2-fluoro-6-methyl-phenyl)-amide

pyridine-2-carboxylic acid (2-bromomethyl-6-fluoro-phenyl)-amide

1-(2-fluoro-6-methylphenyl)-2,2,5,5-tetramethyl-1,2,5-azadisilolidine

Refernces

• 1、 -. "Substituted 1,2,4-triazolo[1,5-a]pyrimidine-2-sulfonamides, compositions containing them, and their utility as herbicides". . . Retrieved 2008/06/13.