1,1-dimethylethyl ((1S)-2-{[3-({[3-fluoro-4-(5-methyl-2-furanyl)phenyl]sulfonyl}amino)-4-(methyloxy)phenyl]amino}-1-methyl-2-oxoethyl)methylcarbamate

Base Information

Chemical Name:1,1-dimethylethyl ((1S)-2-{[3-({[3-fluoro-4-(5-methyl-2-furanyl)phenyl]sulfonyl}amino)-4-(methyloxy)phenyl]amino}-1-methyl-2-oxoethyl)methylcarbamate
CAS No.:953391-72-5
Molecular Formula:C₂₇H₃₂FN₃O₇S
Molecular Weight:561.631
Hs Code.:

1,1-dimethylethyl ((1S)-2-{[3-({[3-fluoro-4-(5-methyl-2-furanyl)phenyl]sulfonyl}amino)-4-(methyloxy)phenyl]amino}-1-methyl-2-oxoethyl)methylcarbamate

Synonyms:1,1-dimethylethyl ((1S)-2-{[3-({[3-fluoro-4-(5-methyl-2-furanyl)phenyl]sulfonyl}amino)-4-(methyloxy)phenyl]amino}-1-methyl-2-oxoethyl)methylcarbamate

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Chemical Property of 1,1-dimethylethyl ((1S)-2-{[3-({[3-fluoro-4-(5-methyl-2-furanyl)phenyl]sulfonyl}amino)-4-(methyloxy)phenyl]amino}-1-methyl-2-oxoethyl)methylcarbamate

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Technology Process of 1,1-dimethylethyl ((1S)-2-{[3-({[3-fluoro-4-(5-methyl-2-furanyl)phenyl]sulfonyl}amino)-4-(methyloxy)phenyl]amino}-1-methyl-2-oxoethyl)methylcarbamate

There total 4 articles about 1,1-dimethylethyl ((1S)-2-{[3-({[3-fluoro-4-(5-methyl-2-furanyl)phenyl]sulfonyl}amino)-4-(methyloxy)phenyl]amino}-1-methyl-2-oxoethyl)methylcarbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 953391-63-4
N-[5-amino-2-(methyloxy)phenyl]-3-fluoro-4-(5-methyl-2-furanyl)benzenesulfonamide

: 16948-16-6
N-(tert-butoxycarbonyl)-N-methyl-L-alanine

: 953391-72-5
1,1-dimethylethyl ((1S)-2-{[3-({[3-fluoro-4-(5-methyl-2-furanyl)phenyl]sulfonyl}amino)-4-(methyloxy)phenyl]amino}-1-methyl-2-oxoethyl)methylcarbamate

Guidance literature:: With O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; In dichloromethane; at 20 ℃;

Reference yield:

: 953391-61-2
4-bromo-3-fluoro-N-[2-(methyloxy)-5-nitrophenyl]benzenesulfonamide

: 953391-72-5
1,1-dimethylethyl ((1S)-2-{[3-({[3-fluoro-4-(5-methyl-2-furanyl)phenyl]sulfonyl}amino)-4-(methyloxy)phenyl]amino}-1-methyl-2-oxoethyl)methylcarbamate

Guidance literature:: Multi-step reaction with 3 steps

1: sodium carbonate / bis-triphenylphosphine-palladium(II) chloride / 1,2-dimethoxyethane; water / 6 h / Heating / reflux

2: hydrogen / palladium 10% on activated carbon / tetrahydrofuran / 18 - 24 h

3: O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; N-ethyl-N,N-diisopropylamine / dichloromethane / 20 °C

With hydrogen; sodium carbonate; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; bis-triphenylphosphine-palladium(II) chloride; palladium 10% on activated carbon; In tetrahydrofuran; 1,2-dimethoxyethane; dichloromethane; water;

Reference yield:

: 351003-51-5
4-bromo-3-fluorobenzene-1-sulfonyl chloride

: 953391-72-5
1,1-dimethylethyl ((1S)-2-{[3-({[3-fluoro-4-(5-methyl-2-furanyl)phenyl]sulfonyl}amino)-4-(methyloxy)phenyl]amino}-1-methyl-2-oxoethyl)methylcarbamate

Guidance literature:: Multi-step reaction with 4 steps

1: pyridine / dichloromethane / 0.5 - 2 h / 0 - 20 °C

2: sodium carbonate / bis-triphenylphosphine-palladium(II) chloride / 1,2-dimethoxyethane; water / 6 h / Heating / reflux

3: hydrogen / palladium 10% on activated carbon / tetrahydrofuran / 18 - 24 h

4: O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; N-ethyl-N,N-diisopropylamine / dichloromethane / 20 °C

With pyridine; hydrogen; sodium carbonate; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; bis-triphenylphosphine-palladium(II) chloride; palladium 10% on activated carbon; In tetrahydrofuran; 1,2-dimethoxyethane; dichloromethane; water;