2-(2-Fluorophenyl)pyrrolidine

Base Information

• Chemical Name: 2-(2-Fluorophenyl)pyrrolidine
• CAS No.: 72216-04-7
• Molecular Formula: C10H12FN
• Molecular Weight: 165.21
• Hs Code.: 2933990090
• DSSTox Substance ID: DTXSID20394195
• Mol file: 72216-04-7.mol

Synonyms:2-(2-fluorophenyl)pyrrolidine;72216-04-7;2-(2-Fluorophenyl)-pyrrolidine;MFCD02663474;SCHEMBL859148;DTXSID20394195;NOJCVVKIBLHAGW-UHFFFAOYSA-N;STK352540;AKOS000150513;AKOS016343989;AC-5475;CS-W008291;FS-2948;(RS)-2-(2-fluoro-phenyl)-pyrrolidine;SY102416;A9409;AM20041077;BB 0254541;FT-0641397;EN300-49800;J-505629

Chemical Property of 2-(2-Fluorophenyl)pyrrolidine

Chemical Property:

• Vapor Pressure: 0.0887mmHg at 25°C
• Refractive Index: 1.515
• Boiling Point: 219 °C at 760 mmHg
• PKA: 9.37±0.10(Predicted)
• Flash Point: 86.2 °C
• PSA: 12.03000
• Density: 1.078 g/cm³
• LogP: 2.57900
• Storage Temp.: Keep in dark place,Inert atmosphere,Store in freezer, under -20°C
• Solubility.: DMSO (Slightly), Methanol (Slightly)
• Water Solubility.: Slightly soluble in water.
• XLogP3: 1.9
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 1
• Exact Mass: 165.095377549
• Heavy Atom Count: 12
• Complexity: 149

Purity/Quality:

99% ^*data from raw suppliers

2-(2-Fluorophenyl)pyrrolidine ^*data from reagent suppliers

Safty Information:

• Statements: 36/37/38
• Safety Statements: 26-36/37/39

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1CC(NC1)C2=CC=CC=C2F
• Uses: 2-(2-Fluorophenyl)pyrrolidine is an important raw material and intermediate used in organic synthesis, pharmaceuticals, agrochemicals and dyestuff.

Technology Process of 2-(2-Fluorophenyl)pyrrolidine

There total 1 articles about 2-(2-Fluorophenyl)pyrrolidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

C10H10FN → 2-(2-fluorophenyl)pyrrolidine (72216-04-7)

Guidance literature:

With methanol; sodium tetrahydroborate; for 2h; Cooling with ice;

DOI:10.1021/acs.orglett.0c00802

Reference yield: 95.0%

2-(2-fluorophenyl)pyrrolidine (72216-04-7) + 4-bromophenyl isocyanate (2493-02-9) → N-(4-bromophenyl)-2-(2-fluorophenyl)pyrrolidine-1-carboxamide

Guidance literature:

In dichloromethane; at 0 - 20 ℃; for 0.166667h;

DOI:10.1039/c8cc06603e

Reference yield: 69.0%

2-(2-fluorophenyl)pyrrolidine (72216-04-7) + 6-chloro-N-(5-cyclopropyl-1H-pyrazol-3-yl)pyrimidin-4-amine → C20H21FN6

Guidance literature:

With N-ethyl-N,N-diisopropylamine; In isopropyl alcohol; at 120 ℃;

Refernces