methyl 5'-(2-(((4S,5R)-5-(3,5-bis(trifluoromethyl)phenyl)-4-methyl-2-oxooxazolidin-3-yl)methyl)-4,4-dimethylcyclohex-1-enyl)-4'-methoxy-2,2'-dimethylbiphenyl-4-carboxylate

Base Information

Chemical Name:methyl 5'-(2-(((4S,5R)-5-(3,5-bis(trifluoromethyl)phenyl)-4-methyl-2-oxooxazolidin-3-yl)methyl)-4,4-dimethylcyclohex-1-enyl)-4'-methoxy-2,2'-dimethylbiphenyl-4-carboxylate
CAS No.:1621255-13-7
Molecular Formula:C₃₈H₃₉F₆NO₅
Molecular Weight:703.722
Hs Code.:

methyl 5'-(2-(((4S,5R)-5-(3,5-bis(trifluoromethyl)phenyl)-4-methyl-2-oxooxazolidin-3-yl)methyl)-4,4-dimethylcyclohex-1-enyl)-4'-methoxy-2,2'-dimethylbiphenyl-4-carboxylate

Synonyms:methyl 5'-(2-(((4S,5R)-5-(3,5-bis(trifluoromethyl)phenyl)-4-methyl-2-oxooxazolidin-3-yl)methyl)-4,4-dimethylcyclohex-1-enyl)-4'-methoxy-2,2'-dimethylbiphenyl-4-carboxylate

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Chemical Property of methyl 5'-(2-(((4S,5R)-5-(3,5-bis(trifluoromethyl)phenyl)-4-methyl-2-oxooxazolidin-3-yl)methyl)-4,4-dimethylcyclohex-1-enyl)-4'-methoxy-2,2'-dimethylbiphenyl-4-carboxylate

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Technology Process of methyl 5'-(2-(((4S,5R)-5-(3,5-bis(trifluoromethyl)phenyl)-4-methyl-2-oxooxazolidin-3-yl)methyl)-4,4-dimethylcyclohex-1-enyl)-4'-methoxy-2,2'-dimethylbiphenyl-4-carboxylate

There total 8 articles about methyl 5'-(2-(((4S,5R)-5-(3,5-bis(trifluoromethyl)phenyl)-4-methyl-2-oxooxazolidin-3-yl)methyl)-4,4-dimethylcyclohex-1-enyl)-4'-methoxy-2,2'-dimethylbiphenyl-4-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 30.3%

: 1621255-88-6
(4S,5R)-5-(3,5-bis(trifluoromethyl)phenyl)-3-((2-(5-iodo-2-methoxy-4-methylphenyl)-5,5-dimethylcyclohex-1-enyl)methyl)-4-methyloxazolidin-2-one

: 473596-87-1
4-methoxycarbonyl-2-methylbenzeneboronic acid pinacol ester

: 1621255-13-7
methyl 5'-(2-(((4S,5R)-5-(3,5-bis(trifluoromethyl)phenyl)-4-methyl-2-oxooxazolidin-3-yl)methyl)-4,4-dimethylcyclohex-1-enyl)-4'-methoxy-2,2'-dimethylbiphenyl-4-carboxylate

Guidance literature:: With dichloro[1,1'-bis(di-t-butylphosphino)ferrocene]palladium(II); sodium carbonate; In 1,2-dimethoxyethane; water; at 120 ℃; for 0.25h; Microwave irradiation;

Reference yield:

: 5367-32-8
5-methoxy-2-nitrotoluene

: 1621255-13-7
methyl 5'-(2-(((4S,5R)-5-(3,5-bis(trifluoromethyl)phenyl)-4-methyl-2-oxooxazolidin-3-yl)methyl)-4,4-dimethylcyclohex-1-enyl)-4'-methoxy-2,2'-dimethylbiphenyl-4-carboxylate

Guidance literature:: Multi-step reaction with 8 steps

1.1: N-iodo-succinimide; sulfuric acid

2.1: copper; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾ / dimethyl sulfoxide / 16 h / 80 °C

3.1: acetic acid / dichloromethane / 0.5 h / 20 °C

4.1: sodium cyanoborohydride / dichloromethane

5.1: N-ethyl-N,N-diisopropylamine / dichloromethane / 2 h / 0 °C

6.1: hydrogen / methanol / 2 h / 20 °C

7.1: toluene-4-sulfonic acid; sodium nitrite / water; acetonitrile / 2 h / 20 °C

7.2: 1 h / 20 °C

8.1: dichloro[1,1'-bis(di-t-butylphosphino)ferrocene]palladium(II); sodium carbonate / 1,2-dimethoxyethane; water / 0.25 h / 120 °C / Microwave irradiation

With tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; N-iodo-succinimide; dichloro[1,1'-bis(di-t-butylphosphino)ferrocene]palladium(II); sulfuric acid; hydrogen; copper; sodium cyanoborohydride; sodium carbonate; toluene-4-sulfonic acid; acetic acid; N-ethyl-N,N-diisopropylamine; sodium nitrite; In methanol; 1,2-dimethoxyethane; dichloromethane; water; dimethyl sulfoxide; acetonitrile; 8.1: |Suzuki Coupling;

Reference yield:

: 1621256-16-3
C₈H₈INO₃

: 1621255-13-7
methyl 5'-(2-(((4S,5R)-5-(3,5-bis(trifluoromethyl)phenyl)-4-methyl-2-oxooxazolidin-3-yl)methyl)-4,4-dimethylcyclohex-1-enyl)-4'-methoxy-2,2'-dimethylbiphenyl-4-carboxylate

Guidance literature:: Multi-step reaction with 7 steps

1.1: copper; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾ / dimethyl sulfoxide / 16 h / 80 °C

2.1: acetic acid / dichloromethane / 0.5 h / 20 °C

3.1: sodium cyanoborohydride / dichloromethane

4.1: N-ethyl-N,N-diisopropylamine / dichloromethane / 2 h / 0 °C

5.1: hydrogen / methanol / 2 h / 20 °C

6.1: toluene-4-sulfonic acid; sodium nitrite / water; acetonitrile / 2 h / 20 °C

6.2: 1 h / 20 °C

7.1: dichloro[1,1'-bis(di-t-butylphosphino)ferrocene]palladium(II); sodium carbonate / 1,2-dimethoxyethane; water / 0.25 h / 120 °C / Microwave irradiation

With tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; dichloro[1,1'-bis(di-t-butylphosphino)ferrocene]palladium(II); hydrogen; copper; sodium cyanoborohydride; sodium carbonate; toluene-4-sulfonic acid; acetic acid; N-ethyl-N,N-diisopropylamine; sodium nitrite; In methanol; 1,2-dimethoxyethane; dichloromethane; water; dimethyl sulfoxide; acetonitrile; 7.1: |Suzuki Coupling;