(2R,3S)-2-O-tert-butyldiphenylsilyloxy-3,4-O-isopropylidene-3,4-dihydroxybutanal

Base Information

Chemical Name:(2R,3S)-2-O-tert-butyldiphenylsilyloxy-3,4-O-isopropylidene-3,4-dihydroxybutanal
CAS No.:658052-79-0
Molecular Formula:C₂₃H₃₀O₄Si
Molecular Weight:398.574
Hs Code.:

Synonyms:(2R,3S)-2-O-tert-butyldiphenylsilyloxy-3,4-O-isopropylidene-3,4-dihydroxybutanal

Suppliers and Price of (2R,3S)-2-O-tert-butyldiphenylsilyloxy-3,4-O-isopropylidene-3,4-dihydroxybutanal

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of (2R,3S)-2-O-tert-butyldiphenylsilyloxy-3,4-O-isopropylidene-3,4-dihydroxybutanal

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of (2R,3S)-2-O-tert-butyldiphenylsilyloxy-3,4-O-isopropylidene-3,4-dihydroxybutanal

There total 4 articles about (2R,3S)-2-O-tert-butyldiphenylsilyloxy-3,4-O-isopropylidene-3,4-dihydroxybutanal which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

: 658052-78-9
(2S,3S)-2-O-tert-butyldiphenylsilyloxy-3,4-O-isopropylidene-3,4-dihydroxybutanol

: 658052-79-0
(2R,3S)-2-O-tert-butyldiphenylsilyloxy-3,4-O-isopropylidene-3,4-dihydroxybutanal

Guidance literature:: With oxalyl dichloride; dimethyl sulfoxide; triethylamine; In dichloromethane; at -70 ℃; for 1.33333h;
DOI:10.1021/jo0496291

Reference yield:

: 114185-07-8
ethyl (2R)-2-[(1S)-3,3-dimethyl(2,4-dioxolanyl)]-2-hydroxyacetate

: 658052-79-0
(2R,3S)-2-O-tert-butyldiphenylsilyloxy-3,4-O-isopropylidene-3,4-dihydroxybutanal

Guidance literature:: Multi-step reaction with 3 steps

1: imidazole / dimethylformamide / 3 h / 0 - 20 °C

2: 35.39 g / LiBH₄ / diethyl ether; methanol / 3 h / 0 °C

3: 98 percent / (COCl)2; DMSO; Et₃N / CH₂Cl₂ / 1.33 h / -70 °C

With 1H-imidazole; lithium borohydride; oxalyl dichloride; dimethyl sulfoxide; triethylamine; In methanol; diethyl ether; dichloromethane; N,N-dimethyl-formamide; 3: Swern oxidation;
DOI:10.1021/jo0496291

Reference yield:

: 58479-61-1
tert-butylchlorodiphenylsilane

: 658052-79-0
(2R,3S)-2-O-tert-butyldiphenylsilyloxy-3,4-O-isopropylidene-3,4-dihydroxybutanal

Guidance literature:: Multi-step reaction with 3 steps

1: imidazole / dimethylformamide / 3 h / 0 - 20 °C

2: 35.39 g / LiBH₄ / diethyl ether; methanol / 3 h / 0 °C

3: 98 percent / (COCl)2; DMSO; Et₃N / CH₂Cl₂ / 1.33 h / -70 °C

With 1H-imidazole; lithium borohydride; oxalyl dichloride; dimethyl sulfoxide; triethylamine; In methanol; diethyl ether; dichloromethane; N,N-dimethyl-formamide; 3: Swern oxidation;
DOI:10.1021/jo0496291