4-(Nα-trifluoroacetyl-L-glutaminyl)amido-2,6-difluorobenzyl phosphoramide

Base Information

Chemical Name:4-(Nα-trifluoroacetyl-L-glutaminyl)amido-2,6-difluorobenzyl phosphoramide
CAS No.:1028745-49-4
Molecular Formula:C₁₈H₂₃Cl₂F₅N₅O₅P
Molecular Weight:586.283
Hs Code.:

Synonyms:4-(Nα-trifluoroacetyl-L-glutaminyl)amido-2,6-difluorobenzyl phosphoramide

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Chemical Property of 4-(Nα-trifluoroacetyl-L-glutaminyl)amido-2,6-difluorobenzyl phosphoramide

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Technology Process of 4-(Nα-trifluoroacetyl-L-glutaminyl)amido-2,6-difluorobenzyl phosphoramide

There total 8 articles about 4-(Nα-trifluoroacetyl-L-glutaminyl)amido-2,6-difluorobenzyl phosphoramide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 55.0%

: 1028745-49-4
4-(Nα-trifluoroacetyl-L-glutaminyl)amido-2,6-difluorobenzyl phosphoramide

Guidance literature:

Reference yield:

: 1028745-26-7
4-azido-2,6-difluorobenzyl phosphoramide mustard

: C₁₁H₁₅F₃N₂O₆

: 1028745-49-4
4-(Nα-trifluoroacetyl-L-glutaminyl)amido-2,6-difluorobenzyl phosphoramide

Guidance literature:: C₁₁H₁₅F₃N₂O₆; With AlH₂LiSe; In tetrahydrofuran; at 5 ℃; for 0.583333h; Inert atmosphere;

4-azido-2,6-difluorobenzyl phosphoramide mustard; In tetrahydrofuran; at 20 ℃; for 24h; Inert atmosphere;
DOI:10.1016/j.bmc.2016.04.035

Reference yield:

: 2419-34-3
N^α-trifluoroacetyl glutamine

: 1028745-49-4
4-(Nα-trifluoroacetyl-L-glutaminyl)amido-2,6-difluorobenzyl phosphoramide

Guidance literature:: Multi-step reaction with 2 steps

1.1: N-methylcyclohexylamine; triethylamine / tetrahydrofuran; toluene / 0.5 h / -15 - -10 °C

2.1: AlH₂LiSe / tetrahydrofuran / 0.58 h / 5 °C / Inert atmosphere

2.2: 24 h / 20 °C / Inert atmosphere

With N-methylcyclohexylamine; AlH₂LiSe; triethylamine; In tetrahydrofuran; toluene;
DOI:10.1016/j.bmc.2016.04.035