4-[2-(2-aminopyridin-4-yl)-4-(trifluoromethyl)phenoxy]-5-chloro-2-fluoro-N-(5-fluoropyrimidin-2-yl)benzenesulfonamide 4-methylbenzenesulfonate

Base Information

Chemical Name:4-[2-(2-aminopyridin-4-yl)-4-(trifluoromethyl)phenoxy]-5-chloro-2-fluoro-N-(5-fluoropyrimidin-2-yl)benzenesulfonamide 4-methylbenzenesulfonate
CAS No.:1354818-84-0
Molecular Formula:C₇H₈O₃S*C₂₂H₁₃ClF₅N₅O₃S
Molecular Weight:730.093
Hs Code.:

4-[2-(2-aminopyridin-4-yl)-4-(trifluoromethyl)phenoxy]-5-chloro-2-fluoro-N-(5-fluoropyrimidin-2-yl)benzenesulfonamide 4-methylbenzenesulfonate

Synonyms:4-[2-(2-aminopyridin-4-yl)-4-(trifluoromethyl)phenoxy]-5-chloro-2-fluoro-N-(5-fluoropyrimidin-2-yl)benzenesulfonamide 4-methylbenzenesulfonate

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Chemical Property of 4-[2-(2-aminopyridin-4-yl)-4-(trifluoromethyl)phenoxy]-5-chloro-2-fluoro-N-(5-fluoropyrimidin-2-yl)benzenesulfonamide 4-methylbenzenesulfonate

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Technology Process of 4-[2-(2-aminopyridin-4-yl)-4-(trifluoromethyl)phenoxy]-5-chloro-2-fluoro-N-(5-fluoropyrimidin-2-yl)benzenesulfonamide 4-methylbenzenesulfonate

There total 5 articles about 4-[2-(2-aminopyridin-4-yl)-4-(trifluoromethyl)phenoxy]-5-chloro-2-fluoro-N-(5-fluoropyrimidin-2-yl)benzenesulfonamide 4-methylbenzenesulfonate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1354819-24-1
4-[2-(2-aminopyridin-4-yl)-4-(trifluoromethyl)phenoxy]-5-chloro-N-(2,4-dimethoxybenzyl)-2-fluoro-N-(5-fluoropyrimidin-2-yl)benzenesulfonamide

: 104-15-4
toluene-4-sulfonic acid

: 1354818-84-0
4-[2-(2-aminopyridin-4-yl)-4-(trifluoromethyl)phenoxy]-5-chloro-2-fluoro-N-(5-fluoropyrimidin-2-yl)benzenesulfonamide 4-methylbenzenesulfonate

Guidance literature:: 4-[2-(2-aminopyridin-4-yl)-4-(trifluoromethyl)phenoxy]-5-chloro-N-(2,4-dimethoxybenzyl)-2-fluoro-N-(5-fluoropyrimidin-2-yl)benzenesulfonamide; With hydrogenchloride; In 1,4-dioxane; for 18h;

With sodium hydroxide; In water; pH=10;

toluene-4-sulfonic acid; In methanol;

Reference yield:

: 84249-14-9
2-amino-4-bromopyridine

: 1354818-84-0
4-[2-(2-aminopyridin-4-yl)-4-(trifluoromethyl)phenoxy]-5-chloro-2-fluoro-N-(5-fluoropyrimidin-2-yl)benzenesulfonamide 4-methylbenzenesulfonate

Guidance literature:: Multi-step reaction with 4 steps

1.1: sodium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,4-dioxane; water / 18 h / 85 °C / Inert atmosphere

2.1: boron tribromide / dichloromethane / 0 - 20 °C

3.1: potassium carbonate / dimethyl sulfoxide / 18 h

4.1: hydrogenchloride / 1,4-dioxane / 18 h

4.2: pH 10

With hydrogenchloride; boron tribromide; sodium carbonate; potassium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In 1,4-dioxane; dichloromethane; water; dimethyl sulfoxide;

Reference yield:

: 240139-82-6
(2-methoxy-5-(trifluoromethyl)phenyl)boronic acid

: 1354818-84-0
4-[2-(2-aminopyridin-4-yl)-4-(trifluoromethyl)phenoxy]-5-chloro-2-fluoro-N-(5-fluoropyrimidin-2-yl)benzenesulfonamide 4-methylbenzenesulfonate

Guidance literature:: Multi-step reaction with 4 steps

1.1: sodium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,4-dioxane; water / 18 h / 85 °C / Inert atmosphere

2.1: boron tribromide / dichloromethane / 0 - 20 °C

3.1: potassium carbonate / dimethyl sulfoxide / 18 h

4.1: hydrogenchloride / 1,4-dioxane / 18 h

4.2: pH 10

With hydrogenchloride; boron tribromide; sodium carbonate; potassium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In 1,4-dioxane; dichloromethane; water; dimethyl sulfoxide;