N-(2,4-difluorophenyl)-N-[(2S)-3-triphenylmethyloxy-2-hydroxypropyl]-4-methylbenzenesulfonamide

Base Information

Chemical Name:N-(2,4-difluorophenyl)-N-[(2S)-3-triphenylmethyloxy-2-hydroxypropyl]-4-methylbenzenesulfonamide
CAS No.:785805-47-2
Molecular Formula:C₃₅H₃₁F₂NO₄S
Molecular Weight:599.698
Hs Code.:

Synonyms:N-(2,4-difluorophenyl)-N-[(2S)-3-triphenylmethyloxy-2-hydroxypropyl]-4-methylbenzenesulfonamide

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of N-(2,4-difluorophenyl)-N-[(2S)-3-triphenylmethyloxy-2-hydroxypropyl]-4-methylbenzenesulfonamide

Chemical Property:

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Technology Process of N-(2,4-difluorophenyl)-N-[(2S)-3-triphenylmethyloxy-2-hydroxypropyl]-4-methylbenzenesulfonamide

There total 4 articles about N-(2,4-difluorophenyl)-N-[(2S)-3-triphenylmethyloxy-2-hydroxypropyl]-4-methylbenzenesulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

: 65291-30-7,89064-51-7,129940-50-7,69161-59-7
trityl glycidyl ether

: 219499-19-1
N-(2,4-difluorophenyl)-4-methylbenzenesulfonamide

: 785805-47-2
N-(2,4-difluorophenyl)-N-[(2S)-3-triphenylmethyloxy-2-hydroxypropyl]-4-methylbenzenesulfonamide

Guidance literature:: With N-benzyl-N,N,N-triethylammonium chloride; potassium carbonate; In 1,4-dioxane;
DOI:10.1016/j.bmcl.2004.07.039

Reference yield:

: 129940-50-7
(S)-tritylglycidol

: 219499-19-1
N-(2,4-difluorophenyl)-4-methylbenzenesulfonamide

: 785805-47-2
N-(2,4-difluorophenyl)-N-[(2S)-3-triphenylmethyloxy-2-hydroxypropyl]-4-methylbenzenesulfonamide

Guidance literature:: With N-benzyl-N,N,N-triethylammonium chloride; potassium carbonate; In 1,4-dioxane; at 120 ℃; for 5h;
DOI:10.1016/j.bmc.2004.07.048

Reference yield:

: 367-25-9,76563-56-9
2,4-difluorophenylamine

: 785805-47-2
N-(2,4-difluorophenyl)-N-[(2S)-3-triphenylmethyloxy-2-hydroxypropyl]-4-methylbenzenesulfonamide

Guidance literature:: Multi-step reaction with 2 steps

1: 100 percent / pyridine / CH₂Cl₂

2: 100 percent / K₂CO₃; BnEt₃NCl / dioxane

With pyridine; N-benzyl-N,N,N-triethylammonium chloride; potassium carbonate; In 1,4-dioxane; dichloromethane;
DOI:10.1016/j.bmcl.2004.07.039