2-(4-fluorophenyl)-5-(2-methyl-5-((3R,4R,5S,6S)-4,5,6-tris(benzyloxy)-3-(benzyloxymethyl)cyclohex-1-enyl)benzyl)thiophene

Base Information

Chemical Name:2-(4-fluorophenyl)-5-(2-methyl-5-((3R,4R,5S,6S)-4,5,6-tris(benzyloxy)-3-(benzyloxymethyl)cyclohex-1-enyl)benzyl)thiophene
CAS No.:1413373-80-4
Molecular Formula:C₅₃H₄₉FO₄S
Molecular Weight:801.034
Hs Code.:

Synonyms:2-(4-fluorophenyl)-5-(2-methyl-5-((3R,4R,5S,6S)-4,5,6-tris(benzyloxy)-3-(benzyloxymethyl)cyclohex-1-enyl)benzyl)thiophene

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Chemical Property of 2-(4-fluorophenyl)-5-(2-methyl-5-((3R,4R,5S,6S)-4,5,6-tris(benzyloxy)-3-(benzyloxymethyl)cyclohex-1-enyl)benzyl)thiophene

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Technology Process of 2-(4-fluorophenyl)-5-(2-methyl-5-((3R,4R,5S,6S)-4,5,6-tris(benzyloxy)-3-(benzyloxymethyl)cyclohex-1-enyl)benzyl)thiophene

There total 1 articles about 2-(4-fluorophenyl)-5-(2-methyl-5-((3R,4R,5S,6S)-4,5,6-tris(benzyloxy)-3-(benzyloxymethyl)cyclohex-1-enyl)benzyl)thiophene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 83.0%

: 1413373-77-9
(1R,4R,5S,6R)-4,5,6-tris(benzyloxy)-3-(benzyloxymethyl)-1-(3-((5-(4-fluorophenyl)thiophen-2-yl)methyl)-4-methylphenyl)cyclohex-2-enol

: 1413373-80-4
2-(4-fluorophenyl)-5-(2-methyl-5-((3R,4R,5S,6S)-4,5,6-tris(benzyloxy)-3-(benzyloxymethyl)cyclohex-1-enyl)benzyl)thiophene

Guidance literature:: With triethylsilane; boron trifluoride diethyl etherate; In dichloromethane; acetonitrile; at -20 ℃; for 2h; Inert atmosphere;

Reference yield: 45.2%

: 1413373-80-4
2-(4-fluorophenyl)-5-(2-methyl-5-((3R,4R,5S,6S)-4,5,6-tris(benzyloxy)-3-(benzyloxymethyl)cyclohex-1-enyl)benzyl)thiophene

: 1413373-83-7
(1R,2S,3R,4R,5S,6R)-3,4,5-tris(benzyloxy)-2-(benzyloxymethyl)-6-(3-((5-(4-fluorophenyl)thiophen-2-yl)methyl)-4-methylphenyl)cyclohexanol

Guidance literature:: 2-(4-fluorophenyl)-5-(2-methyl-5-((3R,4R,5S,6S)-4,5,6-tris(benzyloxy)-3-(benzyloxymethyl)cyclohex-1-enyl)benzyl)thiophene; With lithium borohydride; dimethylsulfide borane complex; In tetrahydrofuran; at 0 ℃; for 1h; Inert atmosphere; Reflux;

With dihydrogen peroxide; sodium hydroxide; In tetrahydrofuran; water; at -10 - 20 ℃;

Reference yield:

: 1413373-80-4
2-(4-fluorophenyl)-5-(2-methyl-5-((3R,4R,5S,6S)-4,5,6-tris(benzyloxy)-3-(benzyloxymethyl)cyclohex-1-enyl)benzyl)thiophene

: 1413373-92-8
C₂₅H₂₅F₃O₄S

Guidance literature:: Multi-step reaction with 4 steps

1.1: dimethylsulfide borane complex / tetrahydrofuran / 0 - 20 °C / Inert atmosphere

1.2: 4 h / 0 - 20 °C

2.1: Dess-Martin periodane / dichloromethane / 1.5 h / 20 °C

3.1: diethylamino-sulfur trifluoride / 70 °C / Inert atmosphere

4.1: hydrogenchloride; hydrogen / palladium 10% on activated carbon / water; tetrahydrofuran; methanol / 72 h / 20 °C

With hydrogenchloride; diethylamino-sulfur trifluoride; dimethylsulfide borane complex; hydrogen; Dess-Martin periodane; palladium 10% on activated carbon; In tetrahydrofuran; methanol; dichloromethane; water;