methyl 3-<<2-benzyloxy-1-(benzyloxymethyl)ethoxy>methyl>-4-hydroxy-1H-pyrazole-5-carboxamide

Base Information

Chemical Name:methyl 3-<<2-benzyloxy-1-(benzyloxymethyl)ethoxy>methyl>-4-hydroxy-1H-pyrazole-5-carboxamide
CAS No.:136767-53-8
Molecular Formula:C₂₂H₂₅N₃O₅
Molecular Weight:411.458
Hs Code.:

Synonyms:methyl 3-<<2-benzyloxy-1-(benzyloxymethyl)ethoxy>methyl>-4-hydroxy-1H-pyrazole-5-carboxamide

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Chemical Property of methyl 3-<<2-benzyloxy-1-(benzyloxymethyl)ethoxy>methyl>-4-hydroxy-1H-pyrazole-5-carboxamide

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Technology Process of methyl 3-<<2-benzyloxy-1-(benzyloxymethyl)ethoxy>methyl>-4-hydroxy-1H-pyrazole-5-carboxamide

There total 5 articles about methyl 3-<<2-benzyloxy-1-(benzyloxymethyl)ethoxy>methyl>-4-hydroxy-1H-pyrazole-5-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 35.0%

: 136767-42-5
methyl 3-<<2-benzyloxy-1-(benzyloxymethyl)ethoxy>methyl>-4-hydroxy-1H-pyrazole-5-carboxylate

: 136767-53-8
methyl 3-<<2-benzyloxy-1-(benzyloxymethyl)ethoxy>methyl>-4-hydroxy-1H-pyrazole-5-carboxamide

Guidance literature:: With ammonia; In methanol; at 95 ℃; for 5h;
DOI:10.1016/0008-6215(92)84179-V

Reference yield:

: 136767-31-2
methyl 2-<(ethoxycarbonylmethyl)hydrazono>propanoate

: 136767-53-8
methyl 3-<<2-benzyloxy-1-(benzyloxymethyl)ethoxy>methyl>-4-hydroxy-1H-pyrazole-5-carboxamide

Guidance literature:: Multi-step reaction with 5 steps

1: 90 percent / NaOMe / methanol / 4 h / Heating

2: 85 percent / pyridine / 3 h / 90 °C

3: 82 percent / benzoyl peroxide, N-bromosuccinimide, K₂CO₃ / CCl₄ / 2 h / Heating

4: 1) NaH / 1) THF, r.t., 1 h, 2) a) r.t., 15 min, b) 60 deg C, 0.5 h

5: 35 percent / NH₃ / methanol / 5 h / 95 °C

With pyridine; N-Bromosuccinimide; ammonia; sodium methylate; sodium hydride; potassium carbonate; dibenzoyl peroxide; In methanol; tetrachloromethane;
DOI:10.1016/0008-6215(92)84179-V

Reference yield:

: 136767-33-4
methyl 4-acetoxy-1-acetyl-3-methyl-1H-pyrazole-5-carboxylate

: 136767-53-8
methyl 3-<<2-benzyloxy-1-(benzyloxymethyl)ethoxy>methyl>-4-hydroxy-1H-pyrazole-5-carboxamide

Guidance literature:: Multi-step reaction with 3 steps

1: 82 percent / benzoyl peroxide, N-bromosuccinimide, K₂CO₃ / CCl₄ / 2 h / Heating

2: 1) NaH / 1) THF, r.t., 1 h, 2) a) r.t., 15 min, b) 60 deg C, 0.5 h

3: 35 percent / NH₃ / methanol / 5 h / 95 °C

With N-Bromosuccinimide; ammonia; sodium hydride; potassium carbonate; dibenzoyl peroxide; In methanol; tetrachloromethane;
DOI:10.1016/0008-6215(92)84179-V