4-Hydrazinylbenzenesulfonamide;hydron;chloride

Base Information

• Chemical Name: 4-Hydrazinylbenzenesulfonamide;hydron;chloride
• CAS No.: 17852-52-7
• Molecular Formula: C₆H₉N₃O₂S*ClH
• Molecular Weight: 223.683
• Hs Code.: 29350090
• Mol file: 17852-52-7.mol

Synonyms:AKOS015890164

Chemical Property of 4-Hydrazinylbenzenesulfonamide;hydron;chloride

Chemical Property:

• Appearance/Colour: white to light yellow crystal powder
• Melting Point: 149-152 °C(lit.)
• Boiling Point: 434.7 °C at 760 mmHg
• Flash Point: 216.7 °C
• PSA: 106.59000
• Density: 1.644[at 20℃]
• LogP: 2.97600
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• Sensitive.: Hygroscopic
• Water Solubility.: Soluble in water.
• Hydrogen Bond Donor Count: 4
• Hydrogen Bond Acceptor Count: 6
• Rotatable Bond Count: 2
• Exact Mass: 223.0182254
• Heavy Atom Count: 13
• Complexity: 226

Purity/Quality:

99% ^*data from raw suppliers

4-Sulfonamidophenylhydrazine hydrochloride ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xn，Xi
• Hazard Codes: Xn,Xi
• Statements: 22-36/37/38
• Safety Statements: 36-24/25

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: [H+].C1=CC(=CC=C1NN)S(=O)(=O)N.[Cl-]
• Uses: Intermediate in the production of Celebrex. It is a potentially useful intermediate in the production of Celebrex an anti inflammatory drug.

Technology Process of 4-Hydrazinylbenzenesulfonamide;hydron;chloride

There total 5 articles about 4-Hydrazinylbenzenesulfonamide;hydron;chloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.9%

sulfanilamide (63-74-1) → 4-hydrazinobenzene-1-sulfonamide hydrochloride (17852-52-7,27918-19-0)

Guidance literature:

sulfanilamide; With hydrogenchloride; sodium nitrite; In water; at 5 - 15 ℃;

With sodium sulfite; In water; at 0 - 10 ℃; Temperature; Further stages;

Reference yield:

→ 4-hydrazinobenzene-1-sulfonamide hydrochloride (17852-52-7,27918-19-0) + 4-[5-(4-(methyl)phenyl)-3-(trifluoromethyl)-1H-pyrazol-1-yl]benzenesulphonamide (169590-42-5,194044-54-7)

Guidance literature:

Reference yield:

→ 1,1,1-trifluoro-4-(o-tolyl)but-3-yn-2-one + 4-hydrazinobenzene-1-sulfonamide hydrochloride (17852-52-7,27918-19-0)

Guidance literature:

upstream raw materials:

sulfanilamide

4-(aminosulphonyl)benzenediazonium chloride

Downstream raw materials:

4-{N'-[(E)-3-(4-Chloro-phenyl)-1-phenyl-prop-2-en-(E)-ylidene]-hydrazino}-benzenesulfonamide

4-{N'-[(E)-1-(4-Bromo-phenyl)-3-phenyl-prop-2-en-(E)-ylidene]-hydrazino}-benzenesulfonamide

4-(3-(4-bromophenyl)-5-phenyl-4,5-dihydro-1H-pyrazol-1-yl)benzenesulfonamide

4-{N'-[(E)-3-(4-Bromo-phenyl)-1-phenyl-prop-2-en-(E)-ylidene]-hydrazino}-benzenesulfonamide

Refernces

• 1、 Duan, Xiaobo,Wang, Yingxing,Feng, Weipei,Yang, Yaxing,Li, Hongyan,Li, Shenghui,Yang, Xiaobing,Zhang, Jinchao,Wang, Shuxiang,Zhou, Guoqiang,Zhou, Chuanqi. "Design, synthesis and biological evaluation of some novel N-arylpyrazole derivatives bearing the sulfonamide moiety as cytotoxic agents". . p. 271 - 281. Retrieved 2017.
• 2、 Murray, Ben J.,Marsh, Thomas G. F.,Yufit, Dmitri S.,Fox, Mark A.,Harsanyi, Antal,Boulton, Lee T.,Sandford, Graham. "HFO-1234yf as a CF3-Building Block: Synthesis and Chemistry of CF3-Ynones". supporting information. p. 6236 - 6244. Retrieved 2020/09/15.
• 3、 -. "CONTINUOUS PROCESSES FOR THE MANUFACTURE OF CELOCOXIB". Page/Page column 14. . Retrieved 2019/04/26.