methyl 1-(2-aminoethyl)-3-phenyl-1H-indole-6-carboxylate hydrochloride

Base Information

• Chemical Name: methyl 1-(2-aminoethyl)-3-phenyl-1H-indole-6-carboxylate hydrochloride
• CAS No.: 1198592-83-4
• Molecular Formula: C₁₈H₁₈N₂O₂*ClH
• Molecular Weight: 330.814
• Mol file: 1198592-83-4.mol

Synonyms:methyl 1-(2-aminoethyl)-3-phenyl-1H-indole-6-carboxylate hydrochloride

Chemical Property of methyl 1-(2-aminoethyl)-3-phenyl-1H-indole-6-carboxylate hydrochloride

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of methyl 1-(2-aminoethyl)-3-phenyl-1H-indole-6-carboxylate hydrochloride

There total 6 articles about methyl 1-(2-aminoethyl)-3-phenyl-1H-indole-6-carboxylate hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 53.0%

methyl 1-[2-({[(1,1-dimethylethyl)oxy]carbonyl}amino)ethyl]-3-phenyl-1H-indole-6-carboxylate (1198592-76-5) → methyl 1-(2-aminoethyl)-3-phenyl-1H-indole-6-carboxylate hydrochloride (1198592-83-4)

Guidance literature:

With hydrogenchloride; In methanol; water; at 20 ℃;

Reference yield:

indole-6-carboxylic acid methyl ester (50820-65-0) → methyl 1-(2-aminoethyl)-3-phenyl-1H-indole-6-carboxylate hydrochloride (1198592-83-4)

Guidance literature:

Multi-step reaction with 6 steps

1: N-Bromosuccinimide / N,N-dimethyl-formamide / -60 - 20 °C

2: dmap / tetrahydrofuran / 16 h / 20 °C

3: caesium carbonate / Pd tetrakis / 1,2-dimethoxyethane; water / 22 h / Heating; Reflux

4: hydrogenchloride / ethyl acetate

5: caesium carbonate / acetonitrile / 20 °C

6: hydrogenchloride / methanol; water / 20 °C

With hydrogenchloride; dmap; N-Bromosuccinimide; caesium carbonate; Pd tetrakis; In tetrahydrofuran; methanol; 1,2-dimethoxyethane; water; ethyl acetate; N,N-dimethyl-formamide; acetonitrile;

Reference yield:

3-bromoindole-1,6-dicarboxylic acid 1-tert-butyl ester 6-methyl ester (479552-81-3) → methyl 1-(2-aminoethyl)-3-phenyl-1H-indole-6-carboxylate hydrochloride (1198592-83-4)

Guidance literature:

Multi-step reaction with 4 steps

1: caesium carbonate / Pd tetrakis / 1,2-dimethoxyethane; water / 22 h / Heating; Reflux

2: hydrogenchloride / ethyl acetate

3: caesium carbonate / acetonitrile / 20 °C

4: hydrogenchloride / methanol; water / 20 °C

With hydrogenchloride; caesium carbonate; Pd tetrakis; In methanol; 1,2-dimethoxyethane; water; ethyl acetate; acetonitrile;

upstream raw materials:

methyl 1-[2-({[(1,1-dimethylethyl)oxy]carbonyl}amino)ethyl]-3-phenyl-1H-indole-6-carboxylate

indole-6-carboxylic acid methyl ester

3-bromoindole-1,6-dicarboxylic acid 1-tert-butyl ester 6-methyl ester

methyl 3-bromo-1H-indazole-6-carboxylate

Downstream raw materials:

methyl 1-{2-[(2-{[4-(1-methylethyl)phenyl]amino}-2-oxoethyl)amino]ethyl}-3-phenyl-1H-indole-6-carboxylate

methyl 1-{2-[methyl(2-{[4-(1-methylethyl)phenyl]amino}-2-oxoethyl)amino]ethyl}-3-phenyl-1H-indole-6-carboxylate