4-[(hydroxy)(o-tolyl)methyl]piperidine-1-carboxylic acid tert-butyl ester

Base Information

• Chemical Name: 4-[(hydroxy)(o-tolyl)methyl]piperidine-1-carboxylic acid tert-butyl ester
• CAS No.: 1107015-34-8
• Molecular Formula: C₁₈H₂₇NO₃
• Molecular Weight: 305.417

Synonyms:4-[(hydroxy)(o-tolyl)methyl]piperidine-1-carboxylic acid tert-butyl ester

Chemical Property of 4-[(hydroxy)(o-tolyl)methyl]piperidine-1-carboxylic acid tert-butyl ester

Chemical Property:

Purity/Quality:

95%-98% ^*data from raw suppliers

tert-Butyl4-(hydroxy(o-tolyl)methyl)-piperidine-1-carboxylate 97% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

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Technology Process of 4-[(hydroxy)(o-tolyl)methyl]piperidine-1-carboxylic acid tert-butyl ester

There total 1 articles about 4-[(hydroxy)(o-tolyl)methyl]piperidine-1-carboxylic acid tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 79.0%

ortho-tolylmagnesium bromide (932-31-0) + tert butyl 4-formylpiperidine-1-carboxylate (137076-22-3) → 4-[(hydroxy)(o-tolyl)methyl]piperidine-1-carboxylic acid tert-butyl ester (1107015-34-8)

Guidance literature:

ortho-tolylmagnesium bromide; tert butyl 4-formylpiperidine-1-carboxylate; In tetrahydrofuran; at 0 ℃;

With ammonium chloride; In tetrahydrofuran; water;

DOI:10.1016/j.bmcl.2009.10.101

Reference yield: 69.0%

4-[(hydroxy)(o-tolyl)methyl]piperidine-1-carboxylic acid tert-butyl ester (1107015-34-8) → 4-(2-methylbenzoyl)piperidine-1-carboxylic acid tert-butyl ester (912769-10-9)

Guidance literature:

With Dess-Martin periodane; In dichloromethane; at 20 ℃;

DOI:10.1016/j.bmcl.2009.10.101

upstream raw materials:

ortho-tolylmagnesium bromide

tert butyl 4-formylpiperidine-1-carboxylate

Downstream raw materials:

4-(2-methylbenzoyl)piperidine-1-carboxylic acid tert-butyl ester

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