3-iodo-4-(3,4,5-trimethoxyphenyl)-1H-pyrrole-2,5-dicarboxylic acid dimethyl ester

Base Information

Chemical Name:3-iodo-4-(3,4,5-trimethoxyphenyl)-1H-pyrrole-2,5-dicarboxylic acid dimethyl ester
CAS No.:1036355-92-6
Molecular Formula:C₁₇H₁₈INO₇
Molecular Weight:475.237
Hs Code.:

Synonyms:3-iodo-4-(3,4,5-trimethoxyphenyl)-1H-pyrrole-2,5-dicarboxylic acid dimethyl ester

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Chemical Property of 3-iodo-4-(3,4,5-trimethoxyphenyl)-1H-pyrrole-2,5-dicarboxylic acid dimethyl ester

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Technology Process of 3-iodo-4-(3,4,5-trimethoxyphenyl)-1H-pyrrole-2,5-dicarboxylic acid dimethyl ester

There total 5 articles about 3-iodo-4-(3,4,5-trimethoxyphenyl)-1H-pyrrole-2,5-dicarboxylic acid dimethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

: 1036355-90-4
3-(3,4,5-trimethoxyphenyl)-1H-pyrrole-2,5-dicarboxylic acid dimethyl ester

: 1036355-92-6
3-iodo-4-(3,4,5-trimethoxyphenyl)-1H-pyrrole-2,5-dicarboxylic acid dimethyl ester

Guidance literature:: With potassium hydroxide; iodine; In N,N-dimethyl-formamide; at 20 ℃; for 20h;
DOI:10.1016/j.tet.2008.03.038

Reference yield:

: 934-05-4
methyl 4-bromo-1H-pyrrole-2-carboxylate

: 1036355-92-6
3-iodo-4-(3,4,5-trimethoxyphenyl)-1H-pyrrole-2,5-dicarboxylic acid dimethyl ester

Guidance literature:: Multi-step reaction with 5 steps

1.1: trichlorophosphate / dichloromethane / 20 °C

2.1: 1,4-diaza-bicyclo[2.2.2]octane; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / toluene; ethanol; water / 2 h / 110 °C / Microwave irradiation

3.1: sodium dihydrogenphosphate; sodium chlorite / water; dimethyl sulfoxide / 20 °C

4.1: N-ethyl-N,N-diisopropylamine / dichloromethane / 0.5 h

4.2: 20 °C

5.1: potassium hydroxide / N,N-dimethyl-formamide / 0.5 h / 20 °C

5.2: 20 °C / Darkness

With 1,4-diaza-bicyclo[2.2.2]octane; sodium chlorite; sodium dihydrogenphosphate; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; N-ethyl-N,N-diisopropylamine; potassium hydroxide; trichlorophosphate; In ethanol; dichloromethane; water; dimethyl sulfoxide; N,N-dimethyl-formamide; toluene; 2.1: |Suzuki Coupling;
DOI:10.1016/j.tet.2014.11.035

Reference yield:

: 5-formyl-4-(3,4,5-trimethoxyphenyl)-1H-pyrrole-2-carboxylic acid methyl ester

: 1036355-92-6
3-iodo-4-(3,4,5-trimethoxyphenyl)-1H-pyrrole-2,5-dicarboxylic acid dimethyl ester

Guidance literature:: Multi-step reaction with 3 steps

1.1: sodium dihydrogenphosphate; sodium chlorite / water; dimethyl sulfoxide / 20 °C

2.1: N-ethyl-N,N-diisopropylamine / dichloromethane / 0.5 h

2.2: 20 °C

3.1: potassium hydroxide / N,N-dimethyl-formamide / 0.5 h / 20 °C

3.2: 20 °C / Darkness

With sodium chlorite; sodium dihydrogenphosphate; N-ethyl-N,N-diisopropylamine; potassium hydroxide; In dichloromethane; water; dimethyl sulfoxide; N,N-dimethyl-formamide;
DOI:10.1016/j.tet.2014.11.035