C₄₉H₇₄Cl₃N₇O₁₂S

Base Information

• Chemical Name: C₄₉H₇₄Cl₃N₇O₁₂S
• CAS No.: 340270-76-0
• Molecular Formula: C₄₉H₇₄Cl₃N₇O₁₂S
• Molecular Weight: 1091.59
• Mol file: 340270-76-0.mol

Synonyms:C₄₉H₇₄Cl₃N₇O₁₂S

Chemical Property of C₄₉H₇₄Cl₃N₇O₁₂S

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of C₄₉H₇₄Cl₃N₇O₁₂S

There total 17 articles about C₄₉H₇₄Cl₃N₇O₁₂S which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

(S)-methyl 2-((2S)-2-[(tert-butoxycarbonyl)-3-phenylpropanamido]-3-hydroxy)-propanoate (34290-59-0) → C49H74Cl3N7O12S (340270-76-0)

Guidance literature:

Multi-step reaction with 13 steps

1: 90 percent / imidazole / dimethylformamide / 3 h / 20 °C

2: 92 percent / Lawesson's reagent / benzene / 2 h / Heating

3: 93 percent / tetrabutylammonium fluoride / tetrahydrofuran / 0.83 h / 20 °C

4: acetyl chloride / methanol / 3 h / 20 °C

5: diisopropylethylamine; HOBt; DCC / CH₂Cl₂ / 63 h / 0 - 20 °C

6: acetyl chloride / methanol / 7 h / 20 °C

7: 1.85 g / diisopropylethylamine; HOBt; DCC / CH₂Cl₂ / 24 h / 0 - 20 °C

8: acetyl chloride / methanol / 11 h / 20 °C

9: 80 percent / diisopropylethylamine; HOBt; DCC / CH₂Cl₂ / 51 h / 0 - 20 °C

10: acetyl chloride / methanol / 3.5 h / 20 °C

11: 249 mg / diisopropylethylamine; HOBt; 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride / CH₂Cl₂ / 23 h / 0 - 20 °C

12: Cd/Pb; aq. NH₄OAc / tetrahydrofuran / 0.5 h / 20 °C

13: 91 mg / HOBt; 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride / CH₂Cl₂ / 41 h / 0 - 20 °C

With Lawessons reagent; 1H-imidazole; Cd/Pb; ammonium acetate; tetrabutyl ammonium fluoride; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; acetyl chloride; dicyclohexyl-carbodiimide; In tetrahydrofuran; methanol; dichloromethane; N,N-dimethyl-formamide; benzene;

DOI:10.1016/S0040-4020(03)00294-1

Reference yield:

(S)-2-((S)-2-tert-Butoxycarbonylamino-3-phenyl-thiopropionylamino)-3-hydroxy-propionic acid methyl ester (142342-82-3) → C49H74Cl3N7O12S (340270-76-0)

Guidance literature:

Multi-step reaction with 10 steps

1: acetyl chloride / methanol / 3 h / 20 °C

2: diisopropylethylamine; HOBt; DCC / CH₂Cl₂ / 63 h / 0 - 20 °C

3: acetyl chloride / methanol / 7 h / 20 °C

4: 1.85 g / diisopropylethylamine; HOBt; DCC / CH₂Cl₂ / 24 h / 0 - 20 °C

5: acetyl chloride / methanol / 11 h / 20 °C

6: 80 percent / diisopropylethylamine; HOBt; DCC / CH₂Cl₂ / 51 h / 0 - 20 °C

7: acetyl chloride / methanol / 3.5 h / 20 °C

8: 249 mg / diisopropylethylamine; HOBt; 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride / CH₂Cl₂ / 23 h / 0 - 20 °C

9: Cd/Pb; aq. NH₄OAc / tetrahydrofuran / 0.5 h / 20 °C

10: 91 mg / HOBt; 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride / CH₂Cl₂ / 41 h / 0 - 20 °C

With Cd/Pb; ammonium acetate; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; acetyl chloride; dicyclohexyl-carbodiimide; In tetrahydrofuran; methanol; dichloromethane;

DOI:10.1016/S0040-4020(03)00294-1

Reference yield:

(S)-2-((S)-2-tert-Butoxycarbonylamino-3-phenyl-propionylamino)-3-(tert-butyl-dimethyl-silanyloxy)-propionic acid methyl ester (189459-10-7) → C49H74Cl3N7O12S (340270-76-0)

Guidance literature:

Multi-step reaction with 12 steps

1: 92 percent / Lawesson's reagent / benzene / 2 h / Heating

2: 93 percent / tetrabutylammonium fluoride / tetrahydrofuran / 0.83 h / 20 °C

3: acetyl chloride / methanol / 3 h / 20 °C

4: diisopropylethylamine; HOBt; DCC / CH₂Cl₂ / 63 h / 0 - 20 °C

5: acetyl chloride / methanol / 7 h / 20 °C

6: 1.85 g / diisopropylethylamine; HOBt; DCC / CH₂Cl₂ / 24 h / 0 - 20 °C

7: acetyl chloride / methanol / 11 h / 20 °C

8: 80 percent / diisopropylethylamine; HOBt; DCC / CH₂Cl₂ / 51 h / 0 - 20 °C

9: acetyl chloride / methanol / 3.5 h / 20 °C

10: 249 mg / diisopropylethylamine; HOBt; 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride / CH₂Cl₂ / 23 h / 0 - 20 °C

11: Cd/Pb; aq. NH₄OAc / tetrahydrofuran / 0.5 h / 20 °C

12: 91 mg / HOBt; 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride / CH₂Cl₂ / 41 h / 0 - 20 °C

With Lawessons reagent; Cd/Pb; ammonium acetate; tetrabutyl ammonium fluoride; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; acetyl chloride; dicyclohexyl-carbodiimide; In tetrahydrofuran; methanol; dichloromethane; benzene;

DOI:10.1016/S0040-4020(03)00294-1

upstream raw materials:

N-tert-butoxycarbonyl-L-phenylalanine

(S)-methyl 2-((2S)-2-[(tert-butoxycarbonyl)-3-phenylpropanamido]-3-hydroxy)-propanoate

(S)-2-((S)-2-tert-Butoxycarbonylamino-3-phenyl-thiopropionylamino)-3-hydroxy-propionic acid methyl ester

(S)-2-((S)-2-tert-Butoxycarbonylamino-3-phenyl-propionylamino)-3-(tert-butyl-dimethyl-silanyloxy)-propionic acid methyl ester

Downstream raw materials:

C₄₉H₇₂Cl₃N₇O₁₁S