(2S,5S,1R)-5-methyl-2-(1-methyl-1-phenylethyl)cyclohexyl (3S)-4,4,4-trifluoro-3-(4-methoxyanilino)-butanoate

Base Information

• Chemical Name: (2S,5S,1R)-5-methyl-2-(1-methyl-1-phenylethyl)cyclohexyl (3S)-4,4,4-trifluoro-3-(4-methoxyanilino)-butanoate
• CAS No.: 445012-71-5
• Molecular Formula: C₂₇H₃₄F₃NO₃
• Molecular Weight: 477.567
• Mol file: 445012-71-5.mol

Synonyms:(2S,5S,1R)-5-methyl-2-(1-methyl-1-phenylethyl)cyclohexyl (3S)-4,4,4-trifluoro-3-(4-methoxyanilino)-butanoate

Chemical Property of (2S,5S,1R)-5-methyl-2-(1-methyl-1-phenylethyl)cyclohexyl (3S)-4,4,4-trifluoro-3-(4-methoxyanilino)-butanoate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (2S,5S,1R)-5-methyl-2-(1-methyl-1-phenylethyl)cyclohexyl (3S)-4,4,4-trifluoro-3-(4-methoxyanilino)-butanoate

There total 3 articles about (2S,5S,1R)-5-methyl-2-(1-methyl-1-phenylethyl)cyclohexyl (3S)-4,4,4-trifluoro-3-(4-methoxyanilino)-butanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

(+)-(2S,5S,1R)-5-methyl-2-(1-methyl-1-phenylethyl)-cyclohexyl (Z)-4,4,4-trifluoro-3-(4-methoxyanilino)-2-butenoate (445009-12-1) → (2S,5S,1R)-5-methyl-2-(1-methyl-1-phenylethyl)cyclohexyl (3S)-4,4,4-trifluoro-3-(4-methoxyanilino)-butanoate (445012-71-5) + (2S,5S,1R)-5-methyl-2-(1-methyl-1-phenylethyl)cyclohexyl (3R)-4,4,4-trifluoro-3-(4-methoxyanilino)-butanoate

Guidance literature:

With sodium tetrahydroborate; zinc(II) iodide; In dichloromethane; at 20 ℃; for 48h;

DOI:10.1021/jo025621k

Reference yield:

(Z)-2,2,2-trifluoro-N-(4-methoxyphenyl)acetimidoyl chloride (75999-66-5) → (2S,5S,1R)-5-methyl-2-(1-methyl-1-phenylethyl)cyclohexyl (3S)-4,4,4-trifluoro-3-(4-methoxyanilino)-butanoate (445012-71-5)

Guidance literature:

Multi-step reaction with 2 steps

1.1: LDA / tetrahydrofuran; hexane / 1.5 h / -50 °C

1.2: 72 percent / tetrahydrofuran; hexane / -78 °C

2.1: ZnI₂; NaBH₄ / CH₂Cl₂ / 48 h / 20 °C

With sodium tetrahydroborate; zinc(II) iodide; lithium diisopropyl amide; In tetrahydrofuran; hexane; dichloromethane;

DOI:10.1021/jo025621k

Reference yield:

(1R,2S,5R)-5-methyl-2-(1-methyl-1-phenylethyl)cyclohexyl acetate (200432-36-6) → (2S,5S,1R)-5-methyl-2-(1-methyl-1-phenylethyl)cyclohexyl (3S)-4,4,4-trifluoro-3-(4-methoxyanilino)-butanoate (445012-71-5)

Guidance literature:

Multi-step reaction with 2 steps

1.1: LDA / tetrahydrofuran; hexane / 1.5 h / -50 °C

1.2: 72 percent / tetrahydrofuran; hexane / -78 °C

2.1: ZnI₂; NaBH₄ / CH₂Cl₂ / 48 h / 20 °C

With sodium tetrahydroborate; zinc(II) iodide; lithium diisopropyl amide; In tetrahydrofuran; hexane; dichloromethane;

DOI:10.1021/jo025621k

upstream raw materials:

(+)-(2S,5S,1R)-5-methyl-2-(1-methyl-1-phenylethyl)-cyclohexyl (Z)-4,4,4-trifluoro-3-(4-methoxyanilino)-2-butenoate

(Z)-2,2,2-trifluoro-N-(4-methoxyphenyl)acetimidoyl chloride

(1R,2S,5R)-5-methyl-2-(1-methyl-1-phenylethyl)cyclohexyl acetate