6-Mercaptonicotinic acid

Base Information

• Chemical Name: 6-Mercaptonicotinic acid
• CAS No.: 92823-43-3
• Molecular Formula: C₆H₅NO₂S
• Molecular Weight: 155.177
• Mol file: 92823-43-3.mol

Synonyms:6-thioxo-1,6-dihydropyridine-3-carboxylic acid;3-pyridinecarboxylic acid, 1,6-dihydro-6-thioxo-;6-Thioxo-1,6-dihydropyridine-3-carboxylic acid;1,6-dihydro-6-thioxonicotinic acid;6-Mercaptopyridine-3-carboxylic acid;

Chemical Property of 6-Mercaptonicotinic acid

Chemical Property:

• Vapor Pressure: 0.00377mmHg at 25°C
• Melting Point: 260-262 °C (dec.)(lit.)
• Refractive Index: 1.694
• Boiling Point: 259.9 °C at 760 mmHg
• PKA: 3.41±0.10(Predicted)
• Flash Point: 111 °C
• PSA: 80.57000
• Density: 1.49 g/cm³
• LogP: 5.11140

Purity/Quality:

98%,99%, ^*data from raw suppliers

6-Mercaptopyridine-3-carboxylic acid technical grade, 90% ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26

MSDS Files:

SDS file from LookChem

Useful:

• Uses: 6-Mercaptopyridine-3-carboxylic acid may be used in the following processes:Fabrication of nanowell based sensors for the detection of improvised explosive devices (IEDs). Functionalization of gold nanoparticles (AuNPs) for the highly sensitive and selective detection of Cd2+ in colorimetric assay. Preparation of thiolated chitosans, which are thiolated biopolymers exhibiting mucoadhesive, enzyme inhibitory, and permeation enhancing properties.Synthesis of Zinc(II) coordination polymers.

Technology Process of 6-Mercaptonicotinic acid

There total 3 articles about 6-Mercaptonicotinic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 30.0%

6,6'-dithionicotinic acid (15658-35-2) → 6-Mercapto-nicotinic acid (17624-07-6,92823-43-3)

Guidance literature:

With sodium citrate; titanium(III) chloride; In ethanol; water; acetic acid; pH 4.5 to 6.O;

Reference yield:

6-Chloro-3-pyridinecarboxylic acid (5326-23-8) → 6-Mercapto-nicotinic acid (17624-07-6,92823-43-3)

Guidance literature:

With methanol; potassium hydrosulfide; at 130 ℃;

Reference yield:

→ 6-Mercapto-nicotinic acid (17624-07-6,92823-43-3)

Guidance literature:

Chlorid VI, KSH;

upstream raw materials:

6-Chloro-3-pyridinecarboxylic acid

6,6'-dithionicotinic acid

Downstream raw materials:

C₂₀H₁₆BFN₂O₅S

6-(2-hydroxy-5-trifluromethoxy-benzylsulfanyl)-N-(4-fluoro-phenyl)-nicotinamide

C₁₈H₁₂FN₃O₅S

6-(2-boronic pinacol ester-5-methoxy-benzylsulfanyl)-N-(4-fluoro-phenyl)nicotinamide

Refernces

• 1、 -. "Tetracyclic benzimidazole derivatives and combinatorial libraries thereof". . . Retrieved 2008/06/13.