(4R,5S)-5-<(benzyloxycarbonyl)amino>-2,2-dimethyl-4-(2-iodoethynyl)-1,3-dioxane

Base Information

Chemical Name:(4R,5S)-5-<(benzyloxycarbonyl)amino>-2,2-dimethyl-4-(2-iodoethynyl)-1,3-dioxane
CAS No.:105563-23-3
Molecular Formula:C₁₆H₁₈INO₄
Molecular Weight:415.228
Hs Code.:

Synonyms:(4R,5S)-5-<(benzyloxycarbonyl)amino>-2,2-dimethyl-4-(2-iodoethynyl)-1,3-dioxane

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (4R,5S)-5-<(benzyloxycarbonyl)amino>-2,2-dimethyl-4-(2-iodoethynyl)-1,3-dioxane

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Technology Process of (4R,5S)-5-<(benzyloxycarbonyl)amino>-2,2-dimethyl-4-(2-iodoethynyl)-1,3-dioxane

There total 1 articles about (4R,5S)-5-<(benzyloxycarbonyl)amino>-2,2-dimethyl-4-(2-iodoethynyl)-1,3-dioxane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 105563-21-1,105617-38-7
(4R,5S)-5-<(benzyloxycarbonyl)amino>-2,2-dimethyl-4-ethynyl-1,3-dioxane

: 105563-23-3
(4R,5S)-5-<(benzyloxycarbonyl)amino>-2,2-dimethyl-4-(2-iodoethynyl)-1,3-dioxane

Guidance literature:: With methyllithium; iodine; Yield given. Multistep reaction; 1.) THF, ether, -23 deg C, 30 min, 2.) THF, -23 deg C, 30 min;
DOI:10.1021/jo00376a050

Reference yield:

: 105563-23-3
(4R,5S)-5-<(benzyloxycarbonyl)amino>-2,2-dimethyl-4-(2-iodoethynyl)-1,3-dioxane

: 105563-12-0
N-CBZ-dihydrosphingosine

Guidance literature:: Multi-step reaction with 3 steps

1: 1.) copper(I) iodide / 1.) THF, -45 deg C, 1 h, 2.) THF, -45 deg C_. 3 h

2: 71 percent / pyridinium p-toluenesulfonate / methanol / 24 h / Ambient temperature

3: 95 percent / H₂ / 5percent Pt/C / methanol / 0.75 h / 760 Torr

With copper(l) iodide; hydrogen; pyridinium p-toluenesulfonate; platinum on activated charcoal; In methanol;
DOI:10.1021/jo00376a050

Reference yield:

: 105563-23-3
(4R,5S)-5-<(benzyloxycarbonyl)amino>-2,2-dimethyl-4-(2-iodoethynyl)-1,3-dioxane

: 105617-35-4
N-CBZ-cis-sphingosine

Guidance literature:: Multi-step reaction with 3 steps

1: 1.) copper(I) iodide / 1.) THF, -45 deg C, 1 h, 2.) THF, -45 deg C_. 3 h

2: 71 percent / pyridinium p-toluenesulfonate / methanol / 24 h / Ambient temperature

3: 66 percent / H₂ / 5percent Pd/CaCO₃/Pb(OAc)2 / methanol / 1 h / 760 Torr

With copper(l) iodide; hydrogen; pyridinium p-toluenesulfonate; poly(acrylonitrile-co-stryrene); lead acetate; calcium carbonate; In methanol;
DOI:10.1021/jo00376a050