Cbz-D-Leucinol

Base Information

Chemical Name:Cbz-D-Leucinol
CAS No.:166735-51-9
Molecular Formula:C₁₄H₂₁NO₃
Molecular Weight:251.326
Hs Code.:
DSSTox Substance ID:DTXSID00584254
Wikidata:Q82475885
Mol file:166735-51-9.mol

Synonyms:Cbz-D-Leucinol;352535-09-2;166735-51-9;BENZYL N-[(2R)-1-HYDROXY-4-METHYLPENTAN-2-YL]CARBAMATE;N-Z-D-LEUCINOL 97;N-Z-D-LEUCINOL 97;N-Z-D-Leucinol, 97%;SCHEMBL14923444;DTXSID00584254;CS-0356617;F78673;EN300-7114537;J-010307;(R)-Benzyl (1-hydroxy-4-methylpentan-2-yl)carbamate;Benzyl [(2R)-1-hydroxy-4-methylpentan-2-yl]carbamate

Suppliers and Price of Cbz-D-Leucinol

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Sigma-Aldrich
N-Z-D-Leucinol 97%
1g
$ 61.80

Sigma-Aldrich
N-Z-D-Leucinol 97%
5g
$ 209.00

American Custom Chemicals Corporation
N-Z-D-LEUCINOL 95.00%
5G
$ 1016.28

American Custom Chemicals Corporation
N-Z-D-LEUCINOL 95.00%
1G
$ 531.30

Acrotein
Cbz-DL-Leucinol 97%
1g
$ 119.17

Total 6 raw suppliers

Chemical Property of Cbz-D-Leucinol

Chemical Property:

Vapor Pressure:2.92E-07mmHg at 25°C
Melting Point:30-34 °C (lit.)
Boiling Point:404.2±38.0 °C(Predicted)
PKA:11.90±0.46(Predicted)
Density:1.083±0.06 g/cm3(Predicted)
XLogP3:2.5
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:7
Exact Mass:251.15214353
Heavy Atom Count:18
Complexity:237

Purity/Quality:

98%Min ^*data from raw suppliers

N-Z-D-Leucinol 97% ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:
Safety Statements: 22-24/25

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CC(C)CC(CO)NC(=O)OCC1=CC=CC=C1
Isomeric SMILES:CC(C)C[C@H](CO)NC(=O)OCC1=CC=CC=C1

Technology Process of Cbz-D-Leucinol

There total 7 articles about Cbz-D-Leucinol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

: (1-allyloxymethyl-3-methyl-butyl)-carbamic acid benzyl ester

: 166735-51-9
(+/-)-2-[(Benzyloxycarbonyl)amino]-4-methylpentan-1-ol

Guidance literature:: With sodium tetrahydroborate; zirconium(IV) chloride; In tetrahydrofuran; at 0 - 35 ℃;
DOI:10.1246/cl.1999.1223

Reference yield:

: 1070268-73-3
benzyl 1-isobutyl-2,2-dimethoxyethylcarbamate

: 166735-51-9
(+/-)-2-[(Benzyloxycarbonyl)amino]-4-methylpentan-1-ol

Guidance literature:: Multi-step reaction with 2 steps

1: formic acid / water

2: metal hydride

With formic acid; In water;
DOI:10.1007/s00726-011-1117-6

Reference yield:

: 1084820-40-5
1,1-dimethoxy-4-methylpentan-2-one oxime

: 166735-51-9
(+/-)-2-[(Benzyloxycarbonyl)amino]-4-methylpentan-1-ol

Guidance literature:: Multi-step reaction with 4 steps

1: hydrogen / ethanol

2: potassium carbonate / tert-butyl methyl ether; water

3: formic acid / water

4: metal hydride

With formic acid; hydrogen; potassium carbonate; In ethanol; tert-butyl methyl ether; water;
DOI:10.1007/s00726-011-1117-6