N-(5-tert-butyl-1,2-oxazol-3-yl)-3-[4-[5-[2-dimethylaminoethyl(methyl)amino]pyridin-3-yl]triazol-1-yl]-4-methylbenzamide

Base Information

Chemical Name:N-(5-tert-butyl-1,2-oxazol-3-yl)-3-[4-[5-[2-dimethylaminoethyl(methyl)amino]pyridin-3-yl]triazol-1-yl]-4-methylbenzamide
CAS No.:1334682-61-9
Molecular Formula:C₂₇H₃₄N₈O₂
Molecular Weight:502.619
Hs Code.:

Synonyms:N-(5-tert-butyl-1,2-oxazol-3-yl)-3-[4-[5-[2-dimethylaminoethyl(methyl)amino]pyridin-3-yl]triazol-1-yl]-4-methylbenzamide

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Chemical Property of N-(5-tert-butyl-1,2-oxazol-3-yl)-3-[4-[5-[2-dimethylaminoethyl(methyl)amino]pyridin-3-yl]triazol-1-yl]-4-methylbenzamide

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Technology Process of N-(5-tert-butyl-1,2-oxazol-3-yl)-3-[4-[5-[2-dimethylaminoethyl(methyl)amino]pyridin-3-yl]triazol-1-yl]-4-methylbenzamide

There total 5 articles about N-(5-tert-butyl-1,2-oxazol-3-yl)-3-[4-[5-[2-dimethylaminoethyl(methyl)amino]pyridin-3-yl]triazol-1-yl]-4-methylbenzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1334685-39-0
C₂₂H₂₁BrN₆O₂

: 142-25-6
N,N',N'-trimethylenediamine

: 1334682-61-9
N-(5-tert-butyl-1,2-oxazol-3-yl)-3-[4-[5-[2-dimethylaminoethyl(methyl)amino]pyridin-3-yl]triazol-1-yl]-4-methylbenzamide

Guidance literature:: With johnphos; sodium t-butanolate; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; In 1,4-dioxane; at 45 ℃; for 15h; Inert atmosphere;

Reference yield:

: C₈H₆ClN₃O

: 1334682-61-9
N-(5-tert-butyl-1,2-oxazol-3-yl)-3-[4-[5-[2-dimethylaminoethyl(methyl)amino]pyridin-3-yl]triazol-1-yl]-4-methylbenzamide

Guidance literature:: Multi-step reaction with 3 steps

1.1: N-ethyl-N,N-diisopropylamine / dichloromethane / 0.5 h / 20 °C

2.1: potassium carbonate / methanol / 12 h / 20 °C

2.2: 15 h / 45 °C

3.1: sodium t-butanolate; johnphos / tris-(dibenzylideneacetone)dipalladium⁽⁰⁾ / 1,4-dioxane / 15 h / 45 °C / Inert atmosphere

With potassium carbonate; N-ethyl-N,N-diisopropylamine; johnphos; sodium t-butanolate; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; In 1,4-dioxane; methanol; dichloromethane; 3.1: Buchwald-Hartwig reaction;

Reference yield:

: 1001203-00-4
C₁₅H₁₇N₅O₂

: 1334682-61-9
N-(5-tert-butyl-1,2-oxazol-3-yl)-3-[4-[5-[2-dimethylaminoethyl(methyl)amino]pyridin-3-yl]triazol-1-yl]-4-methylbenzamide

Guidance literature:: Multi-step reaction with 2 steps

1.1: potassium carbonate / methanol / 12 h / 20 °C

1.2: 15 h / 45 °C

2.1: sodium t-butanolate; johnphos / tris-(dibenzylideneacetone)dipalladium⁽⁰⁾ / 1,4-dioxane / 15 h / 45 °C / Inert atmosphere

With potassium carbonate; johnphos; sodium t-butanolate; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; In 1,4-dioxane; methanol; 2.1: Buchwald-Hartwig reaction;