(1-(4-(2-((1-(3,4-difluorophenyl)-1H-pyrazol-3-yl)methoxy)ethyl)piperazine-1-yl)ethanone)

Base Information

Chemical Name:(1-(4-(2-((1-(3,4-difluorophenyl)-1H-pyrazol-3-yl)methoxy)ethyl)piperazine-1-yl)ethanone)
CAS No.:1351438-26-0
Molecular Formula:C₁₈H₂₂F₂N₄O₂
Molecular Weight:364.395
Hs Code.:

Synonyms:(1-(4-(2-((1-(3,4-difluorophenyl)-1H-pyrazol-3-yl)methoxy)ethyl)piperazine-1-yl)ethanone)

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Chemical Property of (1-(4-(2-((1-(3,4-difluorophenyl)-1H-pyrazol-3-yl)methoxy)ethyl)piperazine-1-yl)ethanone)

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Technology Process of (1-(4-(2-((1-(3,4-difluorophenyl)-1H-pyrazol-3-yl)methoxy)ethyl)piperazine-1-yl)ethanone)

There total 5 articles about (1-(4-(2-((1-(3,4-difluorophenyl)-1H-pyrazol-3-yl)methoxy)ethyl)piperazine-1-yl)ethanone) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 83.0%

: (1-(3,4-difluorophenyl)-1H-pyrazol-3-yl)methyl 4-methylbenzenesulfonate

: 83502-55-0
1-[4-(2-hydroxyethyl)-1-piperazinyl]-1-ethanone

: 1351438-26-0
(1-(4-(2-((1-(3,4-difluorophenyl)-1H-pyrazol-3-yl)methoxy)ethyl)piperazine-1-yl)ethanone)

Guidance literature:: 1-[4-(2-hydroxyethyl)-1-piperazinyl]-1-ethanone; With sodium hydride; In tetrahydrofuran; mineral oil; at 0 ℃; for 0.416667h;

(1-(3,4-difluorophenyl)-1H-pyrazol-3-yl)methyl 4-methylbenzenesulfonate; In tetrahydrofuran; at 20 ℃; for 19.4167h;

Reference yield:

: [1-(3,4-difluorophenyl)-1H-pyrazol-3-yl]methyl-4-methylbenzenesulfonate

: 1176419-58-1
1-(4-(2-hydroxyethyl)piperazin-1-yl)ethanone hydrochloride

: 1351438-26-0
(1-(4-(2-((1-(3,4-difluorophenyl)-1H-pyrazol-3-yl)methoxy)ethyl)piperazine-1-yl)ethanone)

Guidance literature:: [1-(3,4-difluorophenyl)-1H-pyrazol-3-yl]methyl-4-methylbenzenesulfonate; With sodium hydride; In tetrahydrofuran; mineral oil; for 0.5h;

1-(4-(2-hydroxyethyl)piperazin-1-yl)ethanone hydrochloride; In tetrahydrofuran; mineral oil; at 20 ℃;

Reference yield:

: 64248-58-4
1,2-difluoro-4-iodo-benzene

: 1351438-26-0
(1-(4-(2-((1-(3,4-difluorophenyl)-1H-pyrazol-3-yl)methoxy)ethyl)piperazine-1-yl)ethanone)

Guidance literature:: Multi-step reaction with 4 steps

1.1: copper(l) iodide; caesium carbonate; N,N,N,N,-tetramethylethylenediamine / acetonitrile / 85 °C / Inert atmosphere

2.1: lithium borohydride / tetrahydrofuran / Inert atmosphere; Reflux

3.1: potassium hydroxide / tetrahydrofuran / 20 °C

4.1: sodium hydride / tetrahydrofuran; mineral oil / 0.5 h

4.2: 20 °C

With copper(l) iodide; lithium borohydride; N,N,N,N,-tetramethylethylenediamine; sodium hydride; caesium carbonate; potassium hydroxide; In tetrahydrofuran; acetonitrile; mineral oil; 1.1: |Ullmann-Goldberg Substitution;