3-(2-bromo-4-fluorophenoxy)-5-(3-methoxyphenylthio)-N-(4-(piperidin-4-yl)thiazol-2-yl)pyridin-2-amine

Base Information

Chemical Name:3-(2-bromo-4-fluorophenoxy)-5-(3-methoxyphenylthio)-N-(4-(piperidin-4-yl)thiazol-2-yl)pyridin-2-amine
CAS No.:953044-35-4
Molecular Formula:C₂₆H₂₄BrFN₄O₂S₂
Molecular Weight:587.537
Hs Code.:

Synonyms:3-(2-bromo-4-fluorophenoxy)-5-(3-methoxyphenylthio)-N-(4-(piperidin-4-yl)thiazol-2-yl)pyridin-2-amine

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Chemical Property of 3-(2-bromo-4-fluorophenoxy)-5-(3-methoxyphenylthio)-N-(4-(piperidin-4-yl)thiazol-2-yl)pyridin-2-amine

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Technology Process of 3-(2-bromo-4-fluorophenoxy)-5-(3-methoxyphenylthio)-N-(4-(piperidin-4-yl)thiazol-2-yl)pyridin-2-amine

There total 10 articles about 3-(2-bromo-4-fluorophenoxy)-5-(3-methoxyphenylthio)-N-(4-(piperidin-4-yl)thiazol-2-yl)pyridin-2-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

: 953045-85-7
tert-butyl 4-(2-(3-(2-bromo-4-fluorophenoxy)-5-(3-methoxyphenylthio)pyridin-2-ylamino)thiazol-4-yl)piperidine-1-carboxylate

: 953044-35-4
3-(2-bromo-4-fluorophenoxy)-5-(3-methoxyphenylthio)-N-(4-(piperidin-4-yl)thiazol-2-yl)pyridin-2-amine

Guidance literature:: tert-butyl 4-(2-(3-(2-bromo-4-fluorophenoxy)-5-(3-methoxyphenylthio)pyridin-2-ylamino)thiazol-4-yl)piperidine-1-carboxylate; With trifluoroacetic acid; In dichloromethane; at 20 ℃; for 0.0833333h;

With sodium carbonate; In dichloromethane; water;

Reference yield:

: 573675-25-9
5-bromo-3-nitropyridine-2-carbonitrile

: 953044-35-4
3-(2-bromo-4-fluorophenoxy)-5-(3-methoxyphenylthio)-N-(4-(piperidin-4-yl)thiazol-2-yl)pyridin-2-amine

Guidance literature:: Multi-step reaction with 9 steps

1.1: sodium hydride / N,N-dimethyl-formamide / 0.25 h / 0 °C

1.2: 0.33 h / 0 °C

2.1: sodium hydride / N,N-dimethyl-formamide / 0.5 h / 0 °C

3.1: potassium hydroxide; water / ethanol / Heating / reflux

3.2: 20 °C

4.1: diphenyl phosphoryl azide; triethylamine / toluene / 0.17 h / 100 °C

5.1: hydrogenchloride / 1,4-dioxane; methanol; dichloromethane / 20 °C

6.1: tetrahydrofuran / 20 °C

7.1: sodium hydroxide / ethanol / 50 °C

8.1: triethylamine / ethanol / 2 h / 70 °C

9.1: trifluoroacetic acid / dichloromethane / 0.08 h / 20 °C

With hydrogenchloride; potassium hydroxide; sodium hydroxide; diphenyl phosphoryl azide; water; sodium hydride; triethylamine; trifluoroacetic acid; In tetrahydrofuran; 1,4-dioxane; methanol; ethanol; dichloromethane; N,N-dimethyl-formamide; toluene;

Reference yield:

: 1065609-78-0
5-bromo-3-(2-bromo-4-fluorophenoxy)picolinonitrile

: 953044-35-4
3-(2-bromo-4-fluorophenoxy)-5-(3-methoxyphenylthio)-N-(4-(piperidin-4-yl)thiazol-2-yl)pyridin-2-amine

Guidance literature:: Multi-step reaction with 8 steps

1.1: sodium hydride / N,N-dimethyl-formamide / 0.5 h / 0 °C

2.1: potassium hydroxide; water / ethanol / Heating / reflux

2.2: 20 °C

3.1: diphenyl phosphoryl azide; triethylamine / toluene / 0.17 h / 100 °C

4.1: hydrogenchloride / 1,4-dioxane; methanol; dichloromethane / 20 °C

5.1: tetrahydrofuran / 20 °C

6.1: sodium hydroxide / ethanol / 50 °C

7.1: triethylamine / ethanol / 2 h / 70 °C

8.1: trifluoroacetic acid / dichloromethane / 0.08 h / 20 °C

With hydrogenchloride; potassium hydroxide; sodium hydroxide; diphenyl phosphoryl azide; water; sodium hydride; triethylamine; trifluoroacetic acid; In tetrahydrofuran; 1,4-dioxane; methanol; ethanol; dichloromethane; N,N-dimethyl-formamide; toluene;