D-1-[6-(N,N-dibenzylamino)-6-(benzyloxycarbonyl)]-transhex-2-enoyl-3-amino-1,1,1-trifluoro-2-butanol

Base Information

Chemical Name:D-1-[6-(N,N-dibenzylamino)-6-(benzyloxycarbonyl)]-transhex-2-enoyl-3-amino-1,1,1-trifluoro-2-butanol
CAS No.:1427207-09-7
Molecular Formula:C₃₂H₃₅F₃N₂O₄
Molecular Weight:568.636
Hs Code.:

Synonyms:D-1-[6-(N,N-dibenzylamino)-6-(benzyloxycarbonyl)]-transhex-2-enoyl-3-amino-1,1,1-trifluoro-2-butanol

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Chemical Property of D-1-[6-(N,N-dibenzylamino)-6-(benzyloxycarbonyl)]-transhex-2-enoyl-3-amino-1,1,1-trifluoro-2-butanol

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Technology Process of D-1-[6-(N,N-dibenzylamino)-6-(benzyloxycarbonyl)]-transhex-2-enoyl-3-amino-1,1,1-trifluoro-2-butanol

There total 5 articles about D-1-[6-(N,N-dibenzylamino)-6-(benzyloxycarbonyl)]-transhex-2-enoyl-3-amino-1,1,1-trifluoro-2-butanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

: 1237770-04-5
D-6-(N,N-dibenzylamino)-6-(benzyloxycarbonyl)-trans-hex-2-enoic acid

: 115363-79-6
(2RS-3RS)-1,1,1-trifluoro-3-amino-butan-2-ol hydrochloride

: 1427207-09-7
D-1-[6-(N,N-dibenzylamino)-6-(benzyloxycarbonyl)]-transhex-2-enoyl-3-amino-1,1,1-trifluoro-2-butanol

Guidance literature:: With O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; triethylamine; In N,N-dimethyl-formamide; at 0 - 25 ℃; for 24h;
DOI:10.1021/bi400048s

Reference yield:

: 1237769-99-1
N,N-dibenzyl-D-glutamic acid dibenzyl ester

: 1427207-09-7
D-1-[6-(N,N-dibenzylamino)-6-(benzyloxycarbonyl)]-transhex-2-enoyl-3-amino-1,1,1-trifluoro-2-butanol

Guidance literature:: Multi-step reaction with 4 steps

1: diisobutylaluminium hydride; water / diethyl ether; hexane / 0.5 h / -78 - 25 °C / Inert atmosphere

2: tetrahydrofuran / 1.5 h / 25 °C

3: trifluoroacetic acid / dichloromethane / 1 h / 25 °C

4: triethylamine; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate / N,N-dimethyl-formamide / 24 h / 0 - 25 °C

With water; diisobutylaluminium hydride; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; triethylamine; trifluoroacetic acid; In tetrahydrofuran; diethyl ether; hexane; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/bi400048s

Reference yield:

: 1237770-00-1
D-4-(N,N-dibenzylamino)-4-(benzyloxycarbonyl)butanal

: 1427207-09-7
D-1-[6-(N,N-dibenzylamino)-6-(benzyloxycarbonyl)]-transhex-2-enoyl-3-amino-1,1,1-trifluoro-2-butanol

Guidance literature:: Multi-step reaction with 3 steps

1: tetrahydrofuran / 1.5 h / 25 °C

2: trifluoroacetic acid / dichloromethane / 1 h / 25 °C

3: triethylamine; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate / N,N-dimethyl-formamide / 24 h / 0 - 25 °C

With O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; triethylamine; trifluoroacetic acid; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/bi400048s