N₁-(2-fluorophenyl)-2-phenyl-2,3-dihydro-1H-imidazo[1,2-b]pyrazole-1,7-dicarboxamide

Base Information

• Chemical Name: N₁-(2-fluorophenyl)-2-phenyl-2,3-dihydro-1H-imidazo[1,2-b]pyrazole-1,7-dicarboxamide
• CAS No.: 1355577-33-1
• Molecular Formula: C₁₉H₁₆FN₅O₂
• Molecular Weight: 365.367

Synonyms:N₁-(2-fluorophenyl)-2-phenyl-2,3-dihydro-1H-imidazo[1,2-b]pyrazole-1,7-dicarboxamide

Chemical Property of N₁-(2-fluorophenyl)-2-phenyl-2,3-dihydro-1H-imidazo[1,2-b]pyrazole-1,7-dicarboxamide

Chemical Property:

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Technology Process of N₁-(2-fluorophenyl)-2-phenyl-2,3-dihydro-1H-imidazo[1,2-b]pyrazole-1,7-dicarboxamide

There total 4 articles about N₁-(2-fluorophenyl)-2-phenyl-2,3-dihydro-1H-imidazo[1,2-b]pyrazole-1,7-dicarboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 42.0%

2-phenyl-2,3-dihydro-1Himidazo[1,2-b]pyrazole-7-carboxamide + 1-Fluoro-2-isocyanato-benzene (16744-98-2) → N1-(2-fluorophenyl)-2-phenyl-2,3-dihydro-1H-imidazo[1,2-b]pyrazole-1,7-dicarboxamide (1355577-33-1)

Guidance literature:

In N,N-dimethyl-formamide; at 100 ℃; for 18h;

DOI:10.1016/j.ejmech.2011.11.031

Reference yield:

5-amino-1-(2-hydroxy-2-phenylethyl)-1H-pyrazole-4-carboxamide (946150-88-5) → N1-(2-fluorophenyl)-2-phenyl-2,3-dihydro-1H-imidazo[1,2-b]pyrazole-1,7-dicarboxamide (1355577-33-1)

Guidance literature:

Multi-step reaction with 2 steps

1: sulfuric acid / 0.25 h / 20 °C

2: N,N-dimethyl-formamide / 18 h / 100 °C

With sulfuric acid; In N,N-dimethyl-formamide;

DOI:10.1016/j.ejmech.2011.11.031

Reference yield:

5-amino-1-(2-hydroxy-2-phenylethyl)-1H-pyrazole-4-carbonitrile (946150-87-4) → N1-(2-fluorophenyl)-2-phenyl-2,3-dihydro-1H-imidazo[1,2-b]pyrazole-1,7-dicarboxamide (1355577-33-1)

Guidance literature:

Multi-step reaction with 3 steps

1: sodium hydroxide / ethanol; water / 2 h / Reflux

2: sulfuric acid / 0.25 h / 20 °C

3: N,N-dimethyl-formamide / 18 h / 100 °C

With sulfuric acid; sodium hydroxide; In ethanol; water; N,N-dimethyl-formamide;

DOI:10.1016/j.ejmech.2011.11.031

upstream raw materials:

5-amino-1-(2-hydroxy-2-phenylethyl)-1H-pyrazole-4-carbonitrile

5-amino-1-(2-hydroxy-2-phenylethyl)-1H-pyrazole-4-carboxamide

1-Fluoro-2-isocyanato-benzene

2-hydrazino-1-phenylethanol

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